Caspase抑制剂的结构及合成  

The Structure and Synthesis of Caspase Inhibitors

作　　者：张雁钦[1] 郑松志[1] 陶兰[1] 安胜姬[1] 

机构地区：[1]吉林大学化学学院,长春130021

出　　处：《化学进展》2008年第1期98-104,共7页Progress in Chemistry

摘　　要：Caspase在细胞凋亡中起着关键作用,因此Caspase抑制剂的研究成为当今生命科学领域的重要课题之一。人工合成的Caspase抑制剂主要分为肽类和非肽类。本文着重介绍了常见肽类和非肽类Caspase抑制剂的结构及合成方法,并介绍了相关高活性抑制剂的活性数据。The study on Caspase inhibitors becomes one of the most important tasks in the field of life sciences as Caspase plays a key role in apoptosis. Synthetic Caspase inhibitors mainly include peptide and non-peptide. Peptide is made up of two parts, which are pro-peptide structure and peptide. Non-peptide has no fixed structural model. Its synthesis is usually started from known lead compounds, improving the process of inhibitors, and searching for new effect groups. This paper introduces synthetic methods and structure of common peptide and non-peptide of Caspase inhibitors.

关 键 词：半胱天冬酶 抑制剂 结构 合成方法 

分 类 号：O621.3[理学—有机化学] Q55[理学—化学]