糖尿病患者血浆氧化、丙二醛修饰低密度脂蛋白及其自身抗体水平  

The level of oxidized,malondialdehyde-modified low density lipoproteins and their autoantibodies in patients with diabetes mellitus

作　　者：付丽[1] 汪俊军[1] 强红娟[1] 张春妮[1] 

机构地区：[1]南京军区南京总医院全军临床检验医学研究所,江苏南京210002

出　　处：《检验医学》2008年第1期69-71,共3页Laboratory Medicine

基　　金：国家自然科学基金资助项目(30471649);江苏省自然科学基金青年科技创新人才项目(BK2006529)

摘　　要：目的探讨血浆氧化及丙二醛(MDA)修饰低密度脂蛋白(LDL)及其自身抗体与糖尿病(DM)及其他血脂项目之间的关系。方法选择DM患者、正常对照组各60例。采用酶联免疫吸附试验(ELISA)分别测定铜离子氧化型LDL(ox-LDL)、MDA修饰型LDL(MDA-LDL)及其自身抗体,同时对受检者血脂水平进行检测。结果DM患者血浆ox-LDL、MDA-LDL及其自身抗体水平均明显高于对照组(P<0.01),分别与总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)呈高度正相关,而与高密度脂蛋白胆固醇(HDL-C)呈负相关;且ox-LDL、MDA-LDL分别同其自身抗体呈高度正相关。结论DM患者ox-LDL、MDA-LDL及其自身抗体水平显著升高,可能参与动脉粥样硬化的发生、发展过程。Objective To investigate the correlation of oxidized （ ox）, malondialdehyde-modified （MDA） low density lipoprotein （LDL） and their autoantibodies with diabetes mellitus （DM） and others blood lipids. Methods The levels of plasma ox-LDL, MDA-LDL and their autoantibodies in 60 patients with DM and 60 healthy controls were determined by enzyme-linked immunsorbent assay （ ELISA）, and blood lipid levels were also determined. Results The levels of ox- LDL, MDA-LDL and their autoantibodies in patients with DM were significantly higher than control group （ P 〈 0. 01 ）. The ox-LDL, MDA-LDL and their autoantibodies were found positively related with total cholesterol （TC） , triglyceride （TG） and LDL cholesterol （LDL-C）, while negatively related with high-density lipoprotein cholesterol （HDL-C）. Furthermore, positive relationships were found between ox-LDL, MDA-LDL and their autoantibodies, respectively. Conclusions ox-LDL, MDA-LDL and their autoantibodies increase in DM patients, and may play an important role in atherosclerosis.

关 键 词：低密度脂蛋白 氧化 修饰 自身抗体 糖尿病 动脉粥样硬化 

分 类 号：Q513[生物学—生物化学]