系统性硬化患者血尿β2-微球蛋白含量临床意义  

Significance of β2-microglobulin in serum and urine with systemic sclerosis

作　　者：谢冰[1] 白秀芝[1] 邹霓[1] 吴恩亮[1] 

机构地区：[1]山东省滨州市人民医院风湿免疫科,256610

出　　处：《中国实用医药》2008年第1期22-23,共2页China Practical Medicine

摘　　要：目的探讨血、尿β2-微球蛋白(β2-MG)对系统性硬化(systemic sclerosis,SSC)早期肾损伤的评价意义。方法血尿β2-MG的检测采用酶免分析法。结果本组实验中患者尿β2-MG、血β2-MG含量明显高于健康对照组,虽然SSC患者尿β2-MG升高,但肾受累组与无肾受累组尿β2-MG水平无统计学差异,然而肾受累组血β2-MG水平与无肾受累组比较差异显著。结论血β2-MG是诊断SSC早期肾小球及肾小管损伤的有效指标。Objective To investigate the β2-microglobulin （MG）in serum and urine to diagnosis of early renal involvement in systemic sclerosis（SSC）. Methods Radioimmuoassay was measure serum and urine levers of β2-MG in SSC. Results The levers of serum β2-MG,urine β2-MG in SSC were higher than the levers in controls （P 〈 0. 01 , P 〈 0.05 ）. The levers of urine β2-MG were not indicatrix difference within renal involvement and renal not to be involved （P 〉 0.05 ）. The levers of serum β2-MG were indicatrix difference within renal involvement and renal not to be involved（ P 〈 0. 01 ）. Conclusion Serum β2-MG were the significance level in diagnosis of latent renal involvement in systemic sclerosis.

关 键 词：系统性硬化 血、尿β2-微球蛋白 临床意义 

分 类 号：R593.2[医药卫生—内科学]