动脉粥样硬化患者血清肿瘤坏死因子的改变及氨氯地平对其影响  

Effect of amlodipine on the serum TNF level in patients with atherosclerosis

作　　者：胡启程[1] 孙文悦[2] 

机构地区：[1]吉林省长春市中心医院干部疗区,130051 [2]吉林大学中日联谊医院心内科,长春130033

出　　处：《中国实用医药》2008年第2期15-16,共2页China Practical Medicine

摘　　要：目的探讨动脉粥样硬化患者肿瘤坏死因子(TNF)的改变及氨氯地平对其影响。方法采用酶联免疫吸附法(ELISA法)测定50例动脉粥样硬化及15例健康人(对照组)血清TNF含量。结果动脉粥样硬化组血清TNF含量明显高于对照组(P<0.001),氨氯地平治疗动脉粥样硬化患者血清TNF水平与治疗前相比明显降低(P<0.001)。结论TNF在动脉粥样硬化发病中起重要作用,氨氯地平能降低动脉粥样硬化患者血清TNF水平。Objective To study the effect of serum TNF on atherosclerosis and assess the effect of long acting calcium antagonist on the serum TNF level. Methods The serum TNF were measured by ELISA method in 50 patients with atherosclerosis and 15 health cases is control subjects. Results The serum TNF levels were higher in the atherosclerosis group than in control group （ P 〈 0. 001 ） , in amlodipine therapy group, after treatment TNF decrease clearly （ P 〈 0. 001 ）. Conclusion TNF serum has an important role in pathogenesis of atherosclerosis. Amlodipine could reduce the serum TNF level significantly.

关 键 词：动脉粥样硬化 肿瘤坏死因子 氨氯地平 

分 类 号：R543.5[医药卫生—心血管疾病]