紫外分光光度法测定阿奇霉素干混悬剂的含量  

Determination of caulsuspension's concentration of azithromycin by colorimetry method

作　　者：汪锦飘[1] 林茵[1] 马再鸿[1] 

机构地区：[1]中山大学附属第二医院临床药学部,广州510120

出　　处：《中国实用医药》2008年第4期46-47,共2页China Practical Medicine

摘　　要：目的建立紫外分光光度法测定阿奇霉素干混悬剂的含量。方法依据阿奇霉素与硫酸溶液(75→100)在pH值6.0的磷酸盐缓冲液中反应生成的络合物的光谱特征,选择482nm作为测定波长。结果阿奇霉素浓度在16～96μg/ml之间与吸收度呈良好线性关系(r=0.9997),平均回收率为99.3%(n=5),RSD为0.7%。结论本方法快速、简便,结果准确。Objective To establish caulsuspension＇ s concentration of Azithromycin by colorimetry method. Methods Choose determine wavelength at 482 nm on the basis of Azithromycin reacted with sulfuric acid solution（75→100）,PB （pH = 6. 0）and generated comoles compound＇s optical spectrum characters. Resuits Azithromycin （ 16-96 μg/ml） showed fine linear relationship （ r = 0. 9997 ） with absorbability, average recovery was 99.3% （ n = 5 ） , RSD = 0.7%. Conclusion The method is quick, simple and accurate.

关 键 词：阿奇霉素干混悬剂 紫外分光光度法 含量测定 

分 类 号：R927.2[医药卫生—药学]