乙酰甲喹在绵羊体内的药物动力学研究  

Studies on the pharmacokinetics of Mequindox in sheep

作　　者：黄勇旗[1] 李引乾[1] 杨亚军[1] 苗小楼[2] 谢沄[1] 白东英[1] 陆晨薇[1] 孙黎[1] 马宝祯[1] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100 [2]中国农业科学院畜牧与兽药研究所,甘肃兰州730050

出　　处：《西北农林科技大学学报（自然科学版）》2008年第2期77-81,共5页Journal of Northwest A&F University(Natural Science Edition)

基　　金：“十一五”国家科技支撑计划项目(2006BAD04A05)

摘　　要：【目的】分析乙酰甲喹(Mequindox)在成年绵羊体内的药物动力学过程,为兽医临床合理用药提供理论依据。【方法】绵羊单剂量快速静脉注射乙酰甲喹7 mg/kg,7 h内不同时间12次颈静脉采血,用高效液相色谱法测定血药浓度。【结果】乙酰甲喹在绵羊体内的药物动力学配置符合无吸收因素一室开放模型,其药-时曲线最佳方程为:C=10.833e-0.340 4t;主要药物动力学参数:半衰期(t(1/2))为(2.062 2±0.264 5)h,药-时曲线下面积(AUC)为(32.367 6±2.921 6)μg/mL.h,表观分布容积(Vd)为(0.642 7±0.042 9)L/kg,体清除率(CLB)为(0.217 7±0.019 3)L/(kg.h)。【结论】乙酰甲喹在绵羊体内分布广泛,消除较快。[Objective] Pharmacokinetics parameters of mequindox in 6 sheep were calculated so as to provide proof to veterinary clinica. [Methed] Six sheep were treated with a single dosage of mequindox （7 mg/kg） intravenously and rapidly, while the blood samples were collected from vein within 7 hours after giving drug. The concentrations of mequindox in serum were determined by high performance liquid chromatography（HPLC）. [Result] The one-compartment open model with first-order disabsorption factor adequately described concentrations of mequindox in serum disposition and the best concentration-time equation was C= 10. 833e^-0.340 4t. The primary pharmacokinetics parameters of mequindox were as follows： t1/2 was（2. 062 2±0. 2645） h, AUC was（32. 367 6±2. 921 6） μg/mL . h,Vd was（0. 642 7±0. 042 9） L/kg, CLB was （0. 217 7±0. 019 3） L/（kg . h）. [Conclusion] The distribution of mequindox in vivo was broad, and the elimination of mequindox in vivo was rapid.

关 键 词：乙酰甲喹 绵羊 药物动力学 

分 类 号：S858.26[农业科学—临床兽医学]