高氡暴露地区人群中代谢酶CYP1A1基因多态性与肺癌易感性的关系  

Association between Genetic Polymorphisms of CYP1A1 and Lung Cancer Susceptibility for People Living in High Radon-exposed Area

作　　者：齐雪松[1] 夏英[1] 孙全富[1] 尚兵[1] 吕慧敏 程同心 崔宏星[1] 冯顺治 王利平[1] 王浩 孙粉珍 

机构地区：[1]中国疾病预防控制中心辐射防护与核安全医学所,北京100088 [2]庆阳市人民医院,甘肃庆阳市745100 [3]甘肃庆阳市地方病防治协调领导小组

出　　处：《癌变．畸变．突变》2008年第1期11-14,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家自然科学基金资助项目(30470530;39970235)

摘　　要：背景与目的:研究高氡暴露地区人群中CYP1A1基因多态性与肺癌易感性的关系。材料与方法:采用病例-对照研究方法,以基因体外扩增限制性片段长度多态性分析(RFLP-PCR)技术,对高氡暴露地区53例肺癌患者和72例对照人员进行了代谢酶CYP1A1(MSPⅠ)基因多态性检测,并分析了不同人群中该基因多态性与肺癌发病风险的关系。结果:在氡暴露地区CYP1A1(MSPⅠ)基因杂合型人群的肺癌发病的OR(优势比)值为1.03(95%可信限0.468～2.30)。分层分析:有效剂量<50mSv的人群中CYP1A1(MSPⅠ)基因杂合型的肺癌发病风险增至4.29倍(95%可信限0.582～88.2),年龄在40～59岁人群中CYP1A1(MSPⅠ)基因杂合型的肺癌发病风险是野生型的1.22倍(95%可信限0.145～3.65)。结论:CYP1A1(MSPⅠ)基因多态性与肺癌易感性无显著关联,但CYP1A1(MSPⅠ)基因杂合型对观察人群的肺鳞癌发病风险、有效剂量<50mSv的人群肺癌发病风险、非吸烟人群的肺癌发病风险和40～59岁人群肺癌发病风险均有增高的趋势。BACKGROUND AND AIM： To assess the role of genetic polymorphisms of metabolic enzyme Cytochrome P450 1A1（CYP1A1） in the risk of developing lung cancer for the people living in high radon-exposed area. MATERIALS AND METHODS： A case-control study was performed with 53 lung cancer patients and 72 frequency-matched controls. The associations between genotypes and risk of developing lung cancer were estimated by odds ratios （ORs） and their 95% confidence intervals （CIs） calculated by unconditional logistic regression. RKSULTS： Risk of developing lung cancer for heterozygous CYP1A1 （MSPⅠ ） polymorphism was 1.03-fold （95%CI 0.468-2.28） higher than that for wild type of CYP1A1 （MSP Ⅰ ） polymorphism. Stratified analysis showed that with effective dose 〈 50 mSv the risk of developing lung cancer for heterozygous CYP1A1 （MSP Ⅰ ） polymorphism increased to 4.29-fold （95%CI 0.582-88.2） . In people hetemzygous for CYP1A1 （MSP Ⅰ） polymorphism aged between 40 and 59, the risk of developing lung cancer was 1.22-fold higher than that for wild type of CYP1A1 （MSP Ⅰ） polymorphism. CONCLUSION： The present results indicated genetic polymorphisms of CYP1A1 might increase the risk of developing lung cancer, but the difference was not statistically significant.

关 键 词：氡 CYP1A1 基因多态性 肺癌易感性 

分 类 号：R146[医药卫生—公共卫生与预防医学] R734.2