肾综合征出血热患者外周血循环内皮细胞的检测及临床意义  

Detection and clinical significance of circulating endothelial cell in patients with hemorrhagic fever with renal syndrome

作　　者：盖中涛[1] 张景遥[1] 李婕[1] 蒋雪梅[1] 于丽君[1] 

机构地区：[1]济南市传染病医院,250021

出　　处：《中华传染病杂志》2008年第1期33-35,共3页Chinese Journal of Infectious Diseases

摘　　要：目的探讨肾综合征出血热（HFRS）患者循环内皮细胞（CEC）数量变化的临床意义。方法共纳入72例HFRS患者及30例健康对照者，利用Percoll密度梯度离心法分离外周血CEC进行检测。数据行t检验。结果HFRS患者发热期CEC数量（单位为细胞数／0．9μL）为23．36±11．53，低血压休克期为48．25±18．40，少尿期为17．38±7．38，多尿期为4．56±1.58，恢复期为4．02±1.39，对照组为3．33±2．06，发热期、低血压休克期、少尿期明显高于多尿期、恢复期和健康对照组，差异有统计学意义（P〈0．01）；HFRS发热期各型（轻型、中型、重型和危重型）患者CEC数量与健康对照组比较，差异均有统计学意义（P〈0．01），发热期各型之间CEC数量随着病情加重逐渐增多，各型之间比较差异均有统计学意义（P〈0．01）。结论HFRS患者外周血CEC数量呈动态变化，与病情发展及轻重相关，HFRS患者外周血CEC的早期检测可作为早期诊断、早期预测病情轻重的可靠指标。Objective To investigate clinical significance of changes of circulating endothelial cell（CEC） counts in patients with hemorrhagic fever with renal syndrome（HFRS）. Methods CEC were separated using Percoll density gradient centrifugation in 72 patients with HFRS and 30 healthy controls. The data analysis was performed using t test. Results The CEC counts of HFRS patients in febrile phase, hypotensive phase, oliguric phase, polyuric phase and convalescent phase were （23.36±11.53） /0.9 μL, （48.25±18.40）/0.9 μL, （17.38±7.38）/0.9 μL, （4.56±1.58）/ 0.9μL, （4.02 ± 1.39）/0. 9 μL, respectively. And those of healthy controls were （3.33 ±2.06）/ 0.9μL. The CEC counts in febrile phase, hypotensive phase and oliguric phase were higher than those in polyuric phase, convalescent phase and healthy controls, respectively（P 〈 0.01, respectively）. In febrile phase, the numbers of CEC in different clinical types（mild, moderate, severe and profound） were higher than those in healthy controls（all P 〈 0.01）, and increased with the severity of the disease（P 〈 0.01）. Conclusions The CEC counts in patients with HFRS were changed dynamically and correlated with the development of the disease. So the assay of CEC can be used as a reliable index for the early diagnosis and prediction of the patient＇s conditions.

关 键 词：肾综合征出血热 循环内皮细胞 汉坦病毒 

分 类 号：R512.8[医药卫生—内科学]