一种新型轴流式心脏辅助血泵的研制和初步的动物实验  

Development of a Novel Axial Flow Ventricular Assist Device and its Preliminary Animal Experiment

作　　者：张岩[1] 孙寒松[2] 周建业[1] 张浩[1] 郑哲[1] 李国荣[2] 朱晓东[2] 桂幸民[3] 胡盛寿[1] 

机构地区：[1]卫生部心血管病再生医学重点实验室,北京100037 [2]中国医学科学院中国协和医科大学阜外心血管病研究所阜外心血管医院心血管外科,北京100037 [3]北京航空航天大学能源与动力工程学院,北京100083

出　　处：《中国生物医学工程学报》2008年第1期97-101,106,共6页Chinese Journal of Biomedical Engineering

基　　金：北京市优势专科疾病防治研究(H030930020130);国家863计划项目(2006AA02Z4D3)

摘　　要：目的研制开发一种新型的轴流式心室辅助泵,并对其基本性能和血液相容性能进行测试。方法应用计算流体力学(CFD)计算机辅助设计,利用五坐标数控机床上对其进行加工,并通过体外测试台和动物实验,对血泵的流体力学性能和血液相容性能进行了测试。结果轴流泵在后负荷为100mmHg情况下,流量在5L/min以上。动物实验中,血浆游离血红蛋白的含量为0.05g/dL。结论血泵体外测试所提供的输出压力和流量符合临床心力衰竭患者的需要,动物实验结果表明其血液相容性能较为满意,值得进一步改进。Objective To design and develop blood pumps for left ventricular assist devices. Methods Using computational fluid dynamics （ CFD）, five-axis machine, a prototype of the pump has been designed and fabricated. The pump has been used to conduct in vitro experiments to evaluate the performance of hydraulic performance. The pump has also been tested for hemolysis characteristic through animal experiment. Results At 9000r/min, the pump generates more than 5L/min flow against 100mmHg. The plasma free hemoglobin was 0.05g/dL. Conclusions The results obtained from the prototype hydraulic testing and hemolysis testing indicated an acceptable design for the blood pump, representing a significant step in the development phase of this device.

关 键 词：轴流泵 血泵 计算流体力学(CFD) 体外动力学性能测试 

分 类 号：R318.11[医药卫生—生物医学工程]