纳米羟基磷灰石悬浮液稳定性能的研究  

Study on Stability of Nanometer Hydroxyapatite Water Suspension

作　　者：张园[1] 袁媛[1] 刘昌胜[1] 

机构地区：[1]教育部生物医用材料工程研究中心华东理工大学生物材料所,上海200237

出　　处：《中国生物医学工程学报》2008年第1期108-111,116,共5页Chinese Journal of Biomedical Engineering

基　　金：上海市纳米专项课题(0144nm064)

摘　　要：为了得到稳定分散的纳米羟基磷灰石水悬浮液,以羧甲基纤维素钠(CMCNa)作分散剂,采用吸光率实验考察了羧甲基纤维素钠的用量及超声分散时间对纳米羟基磷灰石水悬浮液稳定性的影响,并对其分散机理进行了初步的探讨。结果表明:CMCNa作分散剂时,能有效地分散纳米羟基磷灰石粒子,得到均匀、稳定的纳米羟基磷灰石水悬浮液体系;当CMCNa用量为0.35wt%、超声时间为150s时分散效果最佳;CMCNa分散后,体系的Zeta电位的绝对值提高了69.82mV;CMCNa对纳米HAP悬浮液的稳定分散作用主要是通过粒子间的静电作用和空间位阻来实现的。由此可见,CMCNa对HAP纳米粒子具有较好的分散效果,是制备高分散稳定HAP的理想分散剂。In order to obtain stable nano-scaled hydroxyaptite （HAP） suspension, sodium carboxymethyl cellulose （CMCNa）, a widely used additive for food and medical, was applied in this study. The effects of the amount of CMCNa and ultrasonic time on the dispersion stability of nano-scaled HAP were studied by the measurement of UV absorbance. The dispersion mechanism was preliminarily discussed as well. The experimental results showed that CMCNa greatly increased the absolute value of Zeta potential of the HAP suspension by 69.82mV, which indicated CMCNa could effectively improve the dispersion stability of the nano-scaled HAP powder in water, and the optimal dispersion conditions were determined as following： CMCNa 0.35wt%, ultrasonic time 150s. The enhancement mechanism of CMCNa might be resulted from the electrostatic stabilization and steric stabilization.

关 键 词：纳米羟基磷灰石 水悬浮液 分散剂 稳定性 

分 类 号：R318.08[医药卫生—生物医学工程]