聚（羟基乙酸-N^ε-苄氧羰基-L-赖氨酸-乳酸）的制备及表征  

Synthesis and Characterization of Poly（LA-co-（Glc-alt-N^ε-Carbonylbenzoxy-L-Lys））

作　　者：徐盈 严琼姣[1] 李娟[1] 李世普[1] 

机构地区：[1]武汉理工大学生物材料与工程中心,武汉430070

出　　处：《中国生物医学工程学报》2008年第1期128-131,共4页Chinese Journal of Biomedical Engineering

基　　金：国家重点基础研究发展计划973项目(2005CB623905)

摘　　要：目的:合成一种新型的带有反应活性基团的聚(乳酸-赖氨酸)共聚物,以改善聚乳酸的细胞亲和性。方法:以Nε-苄氧羰基-L-赖氨酸和溴乙酰溴为起始原料,合成了单体3S-[4-(苄氧羰基氨基)丁基]-吗啉-2,5-二酮,再以辛酸亚锡为催化剂,通过3S-[4-(苄氧羰基氨基)丁基]-吗啉-2,5-二酮与D,L-丙交酯共聚,制备了聚(羟基乙酸-Nε-苄氧羰基-L-赖氨酸-乳酸),并用FT-IR,1H-NMR,13C-NMR对反应产物进行了表征。结果:FT-IR,1H-NMR,13C-NMR谱图表明各步反应产物的生成,根据1H-NMR谱图中质子峰的积分面积之比得到共聚物中各单体的摩尔分数。结论:Nε-苄氧羰基-L-赖氨酸被成功引入到聚乳酸主链中,且共聚物中各组分的含量可通过投料比的不同在较大范围内进行调节。Objective：To synthesize a new copolymer with functional groups in order to increase the cell adhesion of PDLLA. Methods： Poly （ LA-co-（ Glc-alt-N^ε-Carbonylbenzoxy-L-Lys ）） was synthesized by ring opening copolymerization of D, L-lactide with 3S-[ N^ε-（carbonylbenzoxy） -L-lysyl]-2,5-morpholinedione which was prepared by cyclization of N^ε-Bromoacetyl- lys（Z）. The copolymerization was carried out in the bulk at 150℃ using stannous octoate as an initiator and use the mole fractions （0.1, 0.2 and 0.3） of 3-[N^ε-（ carbonylbenzoxy）-L-lysyl]-2,5-morpholinedione in the feed. The copelymers were characterized with FT-IR, ^1H-NMR and ^13C-NMR. Results：The FT- IR, ^1H-NMR and ^13C-NMR showed the synthesis of the products. The mole fractions of 3-[N^ε-（carbonyl benzoxy）-L- lysyl]-2,5-morpholinedione could be calculated from the ^1H-NMR. Conclusion： N^ε-（ Carbonylbenzoxy）-L-lysine was introduced into the main chain of PDLLA. The composition of the copelymer can be adjusted according to the ratio in feed.

关 键 词：聚(羟基乙酸-N^ε-苄氧羰基-L-赖氨酸-乳酸) 3S-[4-(苄氧羰基氨基)丁基]-吗啉-2 5-二酮 D L-丙交酯 制备 表征 

分 类 号：R318.08[医药卫生—生物医学工程]