纳米载药微囊的研究进展  

Progress of Researches on Drug-loaded Nanoparticles

作　　者：赵健[1] 盛燕[1] 单晓茜[1] 章晓兰[1] 袁媛[1] 刘昌胜[1] 

机构地区：[1]教育部医用生物材料工程研究中心华东理工大学,上海200237

出　　处：《生物医学工程学杂志》2008年第1期220-223,共4页Journal of Biomedical Engineering

基　　金：国家“863”攻关项目资助(2004AA-302050);上海市纳米技术基金项目资助(Grant0452nm022)

摘　　要：对载药纳米微囊的研究进展进行了综述,着重介绍了关于囊材的选用、制备技术、表面修饰情况以及生物学评价等方面的内容。并对未来的发展状况进行了展望,随着囊材可生物降解聚合物的发展,新设备的涌现以及纳米微囊的表面修饰方法、工艺过程、释放评价方法以及药物对机体的作用等的深入研究,都将把纳米载药微囊的发展推向更多新的领域。The progress of researches on drug-loaded nanoparticles was summarized in this review. The major emphasis was laid on the selection of wall polymers, technology of preparation, surface modification, investigation of release in vitro and biocompatibility evaluation. Additionally, we envisioned a perspective regarding the development in this field. With the development of synthesis of biodegradable polymer, with the appearance of novel equipment, and with the deep-going studies on modification of nanoparticles surface method, on fabrication of nanoparticles art as well as on evaluation of drug release and reaction between drug and organ, further researches in this field will open up the way to applications of drug-loaded nanoparticles in larger field.

关 键 词：纳米微囊 制备 表面 生物学评价 

分 类 号：R94[医药卫生—药剂学]