缺血性中风患者血糖血脂及内皮素变化与证型的相关性研究  

Research on the Relationship Between the TCM Typing of Acute Cerebral Infarction and the Concentration of Endothelin Blood Glucose Serum Lipid

作　　者：陈炳[1] 万菁[1] 张垣[1] 张志强[1] 胡万华[1] 奚经巧[1] 

机构地区：[1]温州市中医院,浙江温州325000

出　　处：《中华中医药学刊》2008年第2期368-370,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨缺血性中风患者(ACI)血管内皮素(endothelin,ET)、血糖、血脂与中医证型的关系。方法:90例ACI患者分为痰热腑实、风火上扰、肝肾阴虚等3个证型组(各30例),并与30名健康体检者作对照,测定ET、空腹血糖(FBG)、血脂含量。结果:痰热腑实、风火上扰、肝肾阴虚证组ET、FBG、低密度脂蛋白胆固醇(LDL-C)、均显著高于健康对照组(P<0.01);肝肾阴虚、风火上扰、痰热腑实组ET、FBG水平依次升高,且与神经功能缺损呈正相关,而LDL-C水平3组比较无显著性差异(P>0.05)。ACI患者的总胆固醇(TC)及总甘油三酯(TG)与对照组比较无显著性差异(P>0.05)。结论:ET和FBG参与了ACI的病理演变过程,是ACI患者机体邪正斗争的病理产物,可作为病情轻重、预后判断及辫证分型的指标。LDL-C虽与ACI的发生有一定的关系,可能是导致其发生的病理基础之一,但TC、TG与ACI及其证型之间的关系仍不明确。Objective： To explore he relationship between the TCM typing of Acute cerebral infarction and the concentration of endothelin, blood glucose and serum lipid. Methods： 90 eases of acute cerebral infarction were divided into three groups ,include Type of phlegm - heat viscus - sthenie, Up - stirring of Wind - yang,deficiency of liver - yin and kid - yin（ each n = 30） ;While 30 healthy subjects were taken as the control group. Their endothelin, fasting blood glucose and serum lipid were determined. Results ： Compared with the control group , the level of ET, FBG, LDL - C raised significantly in the ACI group（ P 〈 0.01 ） ; the level of ET, FBG in the type of deficiency of liveryin and kid -yin ,Up- stirring of Wind - yang and phlegm - heat viscus - sthenic increased in order;Then the LDL - C concentration among the three groups had insignificant difference（ P 〉 0.05）. Conclusion： ET and FBG participate the formation and development of ACI, they might infer the type of TCM, outcome and serious or not of ACI ; but the relationship between Total - cholesterol, Triglyceride with ACI is unclear.

关 键 词：缺血性中风 中医证型 内皮素 血糖 血脂 

分 类 号：R255.2[医药卫生—中医内科学]