1-(取代硅基甲硫基)甲基-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3.3.3]十一烷的合成与生物活性  

Synthesis and Bioactivity of 1-(Substituted silylmethylthio)methyl-2, 8, 9-trioxa-5-aza-1-silabicyclo[3. 3. 3]undecanes

作　　者：贺峥杰[1] 李正名[1] 杨志强[1] 

机构地区：[1]南开大学元素有机化学研究所,天津300071

出　　处：《高等学校化学学报》1997年第1期76-78,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金重点基金

摘　　要：By the reactlon of (substituted silyl )methanethiols with 1-chloromethyl-2, 8, 9-tri-oxa- 5-aza-1-silabicyclo [3. 3, 3] undecane, eleven novel organosilicon compounds were syn-thesized. Their structures were confirmed by 1H NMR, MS and elementary analysis. A rare rearrangement breakdown pattern was found ln their mass spectra. Preliminary bioassay re-sults showed these compounds have some antitumor activity.By the reactlon of (substituted silyl )methanethiols with 1-chloromethyl-2, 8, 9-tri-oxa- 5-aza-1-silabicyclo [3. 3, 3] undecane, eleven novel organosilicon compounds were syn-thesized. Their structures were confirmed by 1H NMR, MS and elementary analysis. A rare rearrangement breakdown pattern was found ln their mass spectra. Preliminary bioassay re-sults showed these compounds have some antitumor activity.

关 键 词：有机硅化合物 合成 生物活性 

分 类 号：O627.41[理学—有机化学]