血浆脑钠素在肺源性心脏病和高血压性心脏病心力衰竭患者中的比较  

Significance of plasma brain natriuretic peptide in differentiating chronic cor pnlmonale from hypertensive heart failure

作　　者：黄蓓洁[1] 罗艳蓉[2] 徐晓雯[2] 李海玲[2] 

机构地区：[1]浙江省温州医学院研究生院,325035 [2]上海市杨浦区中心医院呼吸内科

出　　处：《中华全科医师杂志》2008年第2期94-96,共3页Chinese Journal of General Practitioners

摘　　要：目的探讨测定血浆脑钠素水平对鉴别肺源性心脏病和高血压性心脏病所致心力衰竭的意义。方法肺源性心脏病、高血压性心脏病患者各30例，测定平均心率和PaO2，通过快速免疫荧光定量分析法测定血浆脑钠素水平，与30名正常健康人进行比较和分析。结果肺源性心脏病和高血压性心脏病两组患者在心力衰竭时血浆脑钠素水平均高于对照组（P〈0．05），其中高血压性心脏病组脑钠素[（597±68）ng/L]明显高于肺源性心脏病组[（179±34）ng／ml，P〈0．01]。结论肺源性心脏病和高血压性心脏病患者心力衰竭时均表现出呼吸困难，血浆脑钠素可以作为鉴别两者的指标之一。Objective To study the significance of plasma brain natriuretie peptide （BNP） in differentiating patients with chronic eor pttlmonale from those with hypertensive heart failure. Methods Thirty eases of eor pulmonale and 30 of hypertensive heart disease were recruited for the study. Heart rate and arterial partial oxygen pressure （PaO2 ） were measured for them, as well as plasma level of BNP was measured by rapid immunofluoreseenee quantitative analysis, with 30 normal healthy persons as controls. Results As compared with the control group, plasma level of BNP increased significantly in patients with chronic cot pulmonale and hypertensive heart failure （ P 〈 0. 05）, and that in those with hypertensive heart failure [ （597 ± 68 ） ng/L ] was significantly higher than that in those with cot pulmonale [ （179 ± 34） ng/L,P 〈 0. 05 ]. Conclusion Plasma level of BNP can be used as an indicator to differentiate cot pulmonale from hypertensive heart failure both with dyspnea.

关 键 词：利钠肽 脑 心脏病 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]