七氟醚和异氟醚对小儿吸入快速诱导麻醉效果的比较  

Comparison of Rapid Inhalation Induction with Sevoflurane and Isoflurane in Children

作　　者：林学武[1] 陈玲[1] 沙磊[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院麻醉科,233004

出　　处：《实用全科医学》2008年第1期31-32,共2页Applied Journal Of General Practice

摘　　要：目的比较小儿吸入七氟醚和异氟醚快速诱导麻醉的效果。方法选择60例3～10岁小儿,随机分为七氟醚组(n=30)吸入6%七氟醚;异氟醚组(n=30)吸入4%异氟醚。观察快速吸入诱导的平稳程度,对循环功能的影响。结果七氟醚组的睫毛反射消失时间及疼痛反应消失的时间明显提前(P<0.01)。异氟醚对呼吸道刺激性较大,吸入之初小儿躲闪、咳嗽、喉痉挛、兴奋以及分泌物增加的发生率明显高于七氟醚组。结论小儿使用6%七氟醚吸入诱导的临床效果较为满意,以七氟醚组的诱导速度最快;异氟醚对呼吸道刺激性较大,并发症明显增多,不宜用作快速吸入诱导药。Objective To observe the effect of rapid inhalation induction with sevoflurane and isofluranc. Methods Sixty children （ ASA Ⅰ ）,3 - 10 years of age,were divided randomly into Group S （ n = 30,received 6% sevoflurane） and Group Ⅰ （ n = 30, received 4% isoflurane）. Elapsed time intervals from face mask application to loss of the eyelash reflex and loss of movement to acupuncture were measured respectively. The irritant effect on the airway,blood pressure,heart rate, and SpO2 during induction were recorded. Results The mean time to loss of the eyelash reflex and the mean time to loss of movement to acupuncture were significantly longer than that（P 〈0.01 ）. The incidence of complication during induction in group S was significantly lower than that in group Ⅰ. The change of blood pressure was similar in two groups. Conclusions 6% sevoflurane can provide satisfactory rapid inhalation induction. The induction time in group S is shorter than that in group Ⅰ. The incidence of complication in group Ⅰ is significantly greater than that in group S.

关 键 词：七氟醚 异氟醚 快速吸入诱导 

分 类 号：R614[医药卫生—麻醉学]