肾病综合征患者甲状腺激素水平及小剂量甲状腺素治疗临床观察  

Study the serum levels of thyroid hormone on patients with primary nephritic syndrome and the efficacy of thyroid hormone treatment

作　　者：聂景蓉[1] 高清源[1] 成小苗[2] 

机构地区：[1]湖南常德职业技术学院附属医院内科,常德415000 [2]中南大学湘雅医院肾内科

出　　处：《中国临床保健杂志》2008年第1期33-34,共2页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨原发性肾病综合征（PNS）患者血清游离甲状腺激素（FT3、FT4）水平及小剂量左旋甲状腺素（L-TH）治疗的疗效。方法对比分析66例PNS患者和60例健康者（健康对照组）的FT3、FT4和促甲状腺素（sTSH）水平；同时将66例肾病综合征患者随机分成两组，左旋甲状腺素组36例，一般治疗组30例，左旋甲状腺素组在常规治疗同时加L-TH 25-50μg／d。比较治疗前后甲状腺素水平及临床疗效。结果PNS组血清FT3、FT4降低，与健康者比较差异有统计学意义（P〈0．01）；左旋甲状腺素组与一般治疗组FT3、FT4及临床疗效治疗前后比较，均得到明显改善（P〈0．01）。结论PNS患者活动期存在甲状腺功能低下，小剂量甲状腺素可作为PNS患者辅助治疗手段。Objective To study the relationship between the sermn levels of thyroid hormone and as well as the effects of thyroxine on patients with primary nephritic syndrome （PNS）. Methods The level of FT3, FT4 and the sTSH in 66 patients with primary nephritic syndrome and 60 heathy controls were tested and compared, 66 patients with primary nephritic syndrowere divided into 2 groups randomly . 36 cases of observation group and 30 eases of control group. The observation group were received routine treatment plus thyroxine （ 25 -50 μg/d, oral）. The serum the level of FT3, FT4, sTSH and Efficiency before and after treatment. Result The level of FT3, FT4 were decreased in patients with PNS, as compared with those of the control group（ P 〈 0.01 ） ,The FT3, FT4 and clinical curative effect were notably improved as compared with those of the control group after the treatment （ P 〈 0. 01 ）. Conclusion Low dose thyroxine Can be used for patients with primary nephritic syndrome with better effect.

关 键 词：肾病综合征 甲状腺素 三碘甲状腺原氨酸 

分 类 号：R692.3[医药卫生—泌尿科学]