中药天年饮对衰老大鼠脑兴奋性氨基酸含量的影响  

Effects of Traditional Chinese Medicine Tiannianyin on EAA Contents in Brain of Aged Rats

作　　者：张文彬[1] 叶红[2] 陈志宏[2] 薛景凤[2] 

机构地区：[1]承德医学院附属医院,河北承德067000 [2]承德医学院,河北承德067000

出　　处：《时珍国医国药》2008年第1期63-64,共2页Lishizhen Medicine and Materia Medica Research

基　　金：河北省中医药管理局项目(No.2006017)

摘　　要：目的观察中药天年饮对衰老大鼠不同脑区兴奋性氨基酸谷氨酸(Glu)和天门冬氨酸(Asp)含量的影响。方法40只SD大鼠随机分为4组,正常组、衰老模型组、天年饮用药组、阴性对照组,每组均为10只。D-半乳糖连续腹腔注射制作亚急性衰老的大鼠模型。采用高效毛细管电泳法检测各组大鼠大脑皮质、海马、下丘脑Glu和Asp的含量。结果衰老大鼠皮质、海马、下丘脑Glu,Asp的含量明显升高(P<0.05,P<0.01);中药天年饮可明显降低衰老大鼠各脑区Glu,Asp的含量(P<0.05,P<0.01)。结论中药天年饮可改善衰老大鼠脑氨基酸类神经递质的代谢,具有延缓脑老化的作用。Objective To observe the effects of traditional Chinese medicine Tiannianyin on excitatory amino acids （EAA） contents in brain of aged rats. Methods 40 SD rats were divided into 4 groups at random： normal group, aging model group, Tiannianyin group and negative control group , and each group had 10 rats. The sub - acute aging model rats were made by injecting D -gal into abdominal cavity continually. High performance capillary electropheresis （HPCE） was used to detect the contents of glutamic acid （ Glu ） and aspartic acid （ Asp ） in cerebral cortex, hippocampus and hypothalamus of rats in each group . Results The Glu and Asp contents in cerebral cortex , hippocampus and hypothalamus of rats in aging model group increased sig nificantly （ compared with normal rats P 〈 0.01, P 〈 0, 05 ） . Traditional Chinese medicine Tiannianyin could decrease the Gluand Asp contents in different brain regions of aged rats obviously （ Tiannianyin group compared with aging model group ： P 〈 0.01, P 〈0.05）. Conclusion Traditional Chinese medicine Tiannianyin can improve the metabolism of amino acids in brain of aged rats , and has the effects of delaying brain aging .

关 键 词：天年饮 衰老 脑 兴奋性氨基酸 

分 类 号：R285.5[医药卫生—中药学]