鼻渊舒口服液对急性鼻窦炎大鼠鼻黏膜中肿瘤坏死因子α的影响  

The Influence of BiYuanshu Oral Liquid on Rat TNF α Expression of Acute Sinusitis nasal Mucosa

作　　者：袁晓辉[1] 熊大经[2] 杨旭[2] 尉瑞[2] 

机构地区：[1]中国人民解放军武装警察部队北京总队第二医院,北京100037 [2]成都中医药大学,四川成都610075

出　　处：《时珍国医国药》2008年第1期120-121,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的探讨鼻渊舒口服液对急性鼻窦炎大鼠鼻黏膜中肿瘤坏死因子α(TNF-α)的影响。方法用不同剂量的鼻渊舒口服液治疗急性鼻窦炎大鼠,同时应用其他常规用药作比较,最终以大鼠鼻黏膜的病理切片观察为探讨依据。结果鼻渊舒口服液可以降低大鼠鼻黏膜中的TNF-α。结论鼻渊舒口服液可以通过调节TNF-α与受体结合和受体后信号传导,下调黏附分子和趋化因子的表达和分泌,减弱白细胞的粘附、游出和聚集,从而发挥抗炎作用,促进急性鼻窦炎的痊愈。Objective To study the influence of BiYuanshu Oral Liquid on rat TNF -α expression of acute sinusitis nasal muco sa. Methods Acute simsitis was treated with BiYuarshu oral liquid in different doses and the pathological section of rat rasal mucosa was observed. Results Bi Yuanshu Oral Liquid could reduce rat TNF - αexpression of nasal mucosa. Conclusion Bi Yuanshu Oral Liquid can adjust the combination and conduction of TNF - α with its receptor, inhibit the expression and secretion of adhesion molecule and chemotatic factor, attenuate sticking, emigration and aggregation, therefore it can exert its anti - inflammatory effect, and promote the recover of acute sinusitis.

关 键 词：急性鼻窦炎 肿瘤坏死因子Α 鼻渊舒口服液 

分 类 号：R285.5[医药卫生—中药学]