流动注射化学发光法测定佐米曲谱坦  

Chemiluminescence determination of zolmitriptan by flow injection analysis

作　　者：史犇[1] 石杰[1] 吴拥军[2] 刘发光[1] 龚炜[1] 

机构地区：[1]郑州大学化学系,郑州450052 [2]郑州大学公共卫生学院,郑州450052

出　　处：《分析试验室》2008年第2期62-64,共3页Chinese Journal of Analysis Laboratory

基　　金：河南省科技攻关(0496430006);河南省自然科学基础研究(0411021200);河南省中青年骨干教师项目资助

摘　　要：在碱性条件下，佐米曲谱坦对鲁米诺-K3[Fe（CN）6]化学发光体系有较强的抑制作用，据此建立了佐米曲谱坦的流动注射化学发光分析法。该法的化学发光抑制值△I与佐米曲谱坦质量浓度在2．0×10^-6～1．2×10^-4g／mL范围内，呈良好的线性关系，检出限为7．6×10^-7g／mL。对2．5×10^5g／mL佐米曲谱坦测定的相对标准偏差为1．2％（n=11）。方法适用于佐米曲谱坦片中佐米曲谱坦的测定。A new flow injection technique was developed for the determination of zolmitriptan based on the inhibition of the chemiluminescence from Luminal-K3 [ Fe（ CN）6 ]-NaOH system. The linear range for Zolmitriptan was 2.0 × 10^-6 1.2× 10^-4 g/mL and the limit of detection was 7.6 × 10^-7 g/mL. The relative standard deviation （ n = 11） was 1.2% for 2.5 × 10^-5 g/mL zolmitriptan. This method was applied to the determination of zolmitriptan in tablets with satisfactory results.

关 键 词：佐米曲谱坦 化学发光抑制 流动注射 

分 类 号：O657.3[理学—分析化学]