阿奇霉素对儿童水样便性空肠弯曲菌肠炎的疗效评价  

Therapeutic effect of azithromycin on Campylobacter jejuni enteritis in children

作　　者：李中跃[1] 马鸣[1] 陈洁[1] 

机构地区：[1]浙江大学医学院附属儿童医院,浙江杭州310003

出　　处：《临床儿科杂志》2008年第2期145-147,共3页Journal of Clinical Pediatrics

摘　　要：目的研究阿奇霉素对水样便性空肠弯曲菌肠炎的疗效。方法31例水样便空肠弯曲菌肠炎住院患儿,经乳胶凝集试验鉴定粪便空肠弯曲菌,随机分成2组。治疗组17例,应用阿奇霉素(因培康)联合黏膜保护剂(思密达)及微生态制剂(培菲康)治疗;对照组14例,仅用黏膜保护剂及微生态制剂。比较两组治疗前后病程、总病程及粪便空肠弯曲菌转阴时间。结果入院前2组临床资料及生化指标差异均无统计学意义。两组病例均取得良好治疗效果,阿奇霉素组在入院后病程、总病程及粪便空肠弯曲菌转阴时间上均短于对照组,差异有统计学意义(P<0.01)。结论应用阿奇霉素治疗水样便性空肠弯曲菌肠炎可以缩短病程及粪便空肠弯曲菌转阴时间。Objectives To study the therapeutic effect of azithromycin on Campylobacter jejuni enteritis in children and to explore the reasonable application of antibiotics. Methods A total of 31 cases of Campylobacter jejuni enteritis with watery stool were recruited in the study. Campylobacterjejuni was detected by latex agglutination test in their stool samples. The cases were randomly divided into two groups. Treatment group （n = 17） were treated with azithromycin combined with mucosal protective agent （Smecta） and probiotic preparation （Bifid Triple Viable Capsule/Powder）, Control group （n = 14） were treated by mucosal protective agent and probiotic preparation without azithromycin. The courses of disease and the duration of Campylobacter jejuni in the stool were compared between the two groups. Results The clinical and biochemical data between two groups were not significantly different. All the patients recovered from the illness completely. The course of disease after therapy, total course of disease and the duration of Campylobacter jejuni in stool were significantly shorter in the treatment group than control group（P 〈 0.01 ）. Conclusions The course of disease and the duration of Campylobacter jejuni in stool are short in children with Campylobacter jejuni enteritis when treated by azithromycin.

关 键 词：阿奇霉素 水样便 空肠弯曲菌 肠炎 

分 类 号：R725.1[医药卫生—儿科]