射频毁损后正常兔肝脏CT与病理变化的相关性研究  

Correlation of CT findings and histopathological changes of the normal rabbit liver after radiofrequency ablation

作　　者：邹立秋[1] 郭辉[2] 杜端明[1] 刘鹏程[1] 谢敬霞[3] 江锦赵[1] 阮继银[1] 袁知东[1] 江国银[1] 

机构地区：[1]北京大学深圳医院放射科,广东深圳518036 [2]北京大学深圳医院血液科,广东深圳518036 [3]北京大学第三医院放射科,北京100083

出　　处：《中国医学影像技术》2008年第1期17-19,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨CT在评价正常肝脏射频消融后病理学动态变化中的价值。方法对20只正常兔肝脏进行射频消融后,将每5只随机分为4组:消融即刻,1周,2周,4周分别进行CT平扫及增强检查后,处死并取出肝脏进行大体病理和镜下病理学检查。结果消融即刻病灶中心为凝固性坏死,CT动脉期周边可见环形强化,病理消融灶周围肝窦充血;1～2周消融灶周围出现稍低密度环,密度低于其外围的肝实质,增强扫描可见环形强化,4周仍可见低或等密度环,但增强动脉期、实质期可清晰显示包膜强化程度减轻。结论螺旋CT多期扫描可反映消融的病理学变化,从而可用于评价肝脏肿瘤射频治疗的效果。Objective To evaluate timed-related histopathological changes of the normal liver in rabbits after radiofrequency ablation （RFA） by spiral CT. Methods Twenty rabbits underwent hepatic RFA were divided 4 groups randomly and killed at 0, 1, 2, 4 weeks after RFA procedure, and all were performed multl-phase CT scan before being killed. The CT-histopathological correlation was investigated. Results Shortly after RFA, the RFA lesion became coagulative necrosis, CT showed hyperdensity around the lesion on arterial phase images, but not on parenchymal phase. At 1 -2 weeks, the lesion was hypodensity, enhanced CT scan showed that a thin hyperemic rim surrounded the central coagulative necrosis. In the 4th weeks, a peripheral fibrovascular restoration rim were more obvious, regular and thicker than at 1 -2 weeks. They were iso- density or hypodendity on CT multi-phase images. Conclusion Spiral CT multi-phase scan can effectively show the histopathological change after RFA, and could be used to evaluate the therapeutic effect of RFA.

关 键 词：肝脏 射频消融 体层摄影术 X线计算机 病理学 

分 类 号：R814.42[医药卫生—影像医学与核医学] R-33[医药卫生—放射医学]