^(18)F-FDG代谢显像综合评价对肺占位病变定性诊断的价值  

Clinical Value of ^(18)F-FDG DHTC Comprehensive Analysis in Differential Diagnosis of Space Occupying Lesions in Lung

作　　者：王蒨[1] 丁健[1] 米宏志[1] 陆遥[1] 田文剑[1] 柏江[1] 赵健冬[1] 郭芳[1] 焦建[1] 

机构地区：[1]首都医科大学附属北京安贞医院核医学科

出　　处：《首都医科大学学报》2008年第1期29-31,共3页Journal of Capital Medical University

摘　　要：目的评价18F-FDG符合线路断层显像(DHTC)和综合分析方法对肺占位性病变定性和鉴别诊断的价值。方法对176例X线胸片显示肺部占位病变患者行18F-FDGDHTC显像,依据病变内FDG摄取状态、靶/非靶比值(T/NT)和综合分析方法诊断肺占位病变的性质,所有结果均与病理资料进行对照分析。结果受试的176例患者中有138例肺内占位病变呈放射性异常增高或浓聚,T/NT值为2.1～18.0,综合分析方法诊断有132例为恶性病变,6例为良性病变,病理学检查证实其中129例为恶性病变,9例为良性病变;176例患者中有38例肺内占位病变呈一般放射性分布,T/NT值为1.0～1.85,综合分析方法诊断有23例为良性病变,15例为恶性病变,病理学检查证实其中22例为良性病变,16例为恶性病变。单纯根据病灶内放射性浓聚程度和T/NT比值与结合综合分析方法诊断肺内占位病变的灵敏度、特异性和准确性分别为88.96%、70.97%、85.80%和96.55%、77.42%、93.18%。结论18F-FDGDHTC显像综合分析方法可明显提高肺占位病变良恶性鉴别诊断的灵敏度、特异性和准确性,对肺内占位病变的定性诊断有较高的临床价值。Objective To evaluate the clinical value of ^18F-FDG DHTC comprehensive analysis in the qualitative diagnosis and differential diagnosis of-space occupying lesions in lung. Methods One hundred and seventy-six patients with lung occupying lesions on the X-ray film were diagnosed by comprehensive analysis, according to the uptake of FDG and the value of T/NT in the affected area. All the results were verified with those of biopsy. Results The space occupying lesions showed markedly increased tracer uptake in 138 patients with values of T/NT 2.1 - 18.0. The analyses showed 132 patients with malignancy and 6 with benign tumors. Lung cancer was proved by biopsy in 129 patients and benign tumors in 9 cases. Comprehensive analyses of 38 cases showing mild uptake with the value of T/NT 1.0 - 1.85 showed 15 malignancy and 23 benign tumors. Confirmed by biopsy results, 16 cases were malignant and 22 benign. The sensitivity, specificity and accuracy of the diagnosis by tracer uptake of lesion alone were 88.96% , 70.97% and 85.80% respectively, while those of comprehensive analysis were 96.55%, 77.42% and 93.18% respectively. Conclusion The sensitivity, specificity and accuracy of the qualitative and differential diagnosis in lung occupying lesion are improved by the ^18F-FDG DHTC comprehensive analysis.

关 键 词：肺占位病变 肺癌 体层摄影术 发射型计算机 脱氧葡萄糖 

分 类 号：R817[医药卫生—影像医学与核医学]