^(18)F-FDG PET显像在胰腺癌诊断中的应用  

The Application of ^(18)F-FDG PET Imaging in the Diagnosis of Pancreatic Cancer

作　　者：王红艳[1] 马云川[1] 李德鹏[1] 苏玉盛[1] 尚建文[1] 张琳瑛[1] 彭程[1] 

机构地区：[1]首都医科大学宣武医院PET中心

出　　处：《首都医科大学学报》2008年第1期42-44,共3页Journal of Capital Medical University

摘　　要：目的探讨胰腺良恶性病变18F-FDGPET显像特征及其在鉴别诊断中的应用价值。方法临床可疑胰腺恶性病变40例,静脉注射18F-FDG40min后行PET显像,获得三维断层影像和标准化摄取值(SUV),并与PET检查前2周内CT结果对照。结果PET诊断恶性病变30例,表现为胰腺病变部位代谢率增高,标准化摄取值>2.0;诊断良性病变10例,表现为局部代谢率轻度增高或不增高,SUV<2.0。24例PET检查结果与CT一致。经组织病理学检查(31例)及临床、放射学随访3～12个月(9例)证实胰腺恶性病变29例,良性病变11例。18F-FDGPET正确诊断胰腺恶性病变28例,良性病变9例,诊断的敏感度为96.6%(28/29)、特异度为81.8%(9/11)、准确度为92.5%(37/40)。CT正确诊断胰腺恶性病变22例,良性病变6例,诊断的敏感度为75.9%(22/29)、特异度为54.5%(6/11)、准确度为70%(28/40)。18F-FDGPET显像还发现6例CT检查未能确定的肝、肺及淋巴结转移灶。结论18F-FDGPET显像对胰腺癌的诊断及临床分期具有较好的应用价值。Objective To assess the value of ^18F-2-fluoro-2-deoxy-d-glucose （FDG） PET in the diagnosis of pancreatic cancer. Methods ^18F-FDG PET imaging was performed on 29 patients with suspected pancreatic malignant tumors, and 11 cases with chronic pancreatitis. The final diagnosis was proved by pathologic results（ n = 31 ） and clinical or radiologic follow-up lasted 3 - 12 months（ n = 9）. PET findings were compared with the results of abdominal CT done within 2 weeks. Fasting blood sugar levels were controlled in 3.9 - 6.7 mmol/L in all patients at first, then 5.55 MBq/kg of ^18F-FDG was injected intravenously, the transmission and emission scans were performed 40 min after injection. The images of FDG PET were analyzed visually and semi-quantitatively using standard uptake value （SUV）. Results PET had a sensitivity of 96.6% （28/ 29） and a specificity of 81.8% （9/ll）in detecting pancreatic cancer in 40 patients, while CT had 75.9% （22/29） and 54.5% （6/11 ）, respectively, ^18F-F-FDG PET had found metastases in liver, lung and lymph nodes which were not detected with CT in 6 cases. Conclusion ^18F-FDG PET is very useful in the diagnosis and clinical staging of pancreatic cancer.

关 键 词：胰腺肿瘤 诊断 正电子发射断层扫描 脱氧葡萄糖 

分 类 号：R817.4[医药卫生—影像医学与核医学]