苍白球毁损术和丘脑毁损术对帕金森病病人发音的影响  

Influence of globus pallidus lesioning and thalamic lesioning on the voice of Parkinson disease patients

作　　者：谢燕[1] 刘爱华[2] 张宇清[3] 庄平[3] 张丽娟[1] 王晓民[1] 李勇杰[3] 

机构地区：[1]首都医科大学生理系,北京100069 [2]首都医科大学附属宣武医院神经内科,北京100053 [3]首都医科大学附属宣武医院功能神经外科北京功能神经外科研究所,北京100053

出　　处：《中国微侵袭神经外科杂志》2008年第2期52-54,共3页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：国家自然科学基金资助项目(30770746)

摘　　要：目的研究帕金森病(PD)病人在单侧苍白球腹后部毁损术(PVP)、丘脑腹中间核(Vim)毁损术前后的发音状况。方法12位PD病人在手术前后分别发持续元音/a:/、/i:/、/u:/,记录发音,提取发音参数基频(F0)及第1、2、3、4共振峰(F1、F2、F3、F4)。结果男性病人行Vim毁损术后,元音/i:/的第1共振峰升高,与术前有显著性差异(P<0.05)。其他各参数无显著性差异。结论单侧PVP和Vim毁损术对PD病人近期发音无明显影响,长期影响仍需进一步观察。Objective To investigate the phonatory characteristics before and after posteroventral pallidotomy （pallidal lesioning） and ventrointermediate thalamic nucleus lesioning in Parkinson disease patients. Methods Twelve Parkinson disease patients were ordered to pronounce sustained vowels/a：/,/i：/,/u：/before and after operation. Acoustic ,signals were obtained during the vowel production and the measures included fundamental frequency （F_0）, and the first, second, third and fourth formant frequency （F_1, F_2, F_3, F_4）. Results In male PD patient, the Fl was significantly higher after the thalamotomy than before the thalamotomy during production of the sustained vowel/i：/（P 〈 0.05）. There was no significant difference in other figures before and after the pallidotomy and thalamotomy. Conclusion There is no change of voice in short-term follow up after the pallidotomy and thalamotomy. The long-term influence needs to be observed.

关 键 词：帕金森病 发音障碍 苍白球腹后部毁损术 丘脑腹中间核毁损术 

分 类 号：R651.1[医药卫生—外科学]