腺苷钴胺的光解研究  

Study on Photolysis of Cobamamide

作　　者：封淑华[1] 李力更[2] 王丽萍[1] 

机构地区：[1]河北省药品检验所,石家庄050011 [2]河北医科大学药学院,石家庄050017

出　　处：《中国药科大学学报》1997年第3期183-186,共4页Journal of China Pharmaceutical University

摘　　要：用HPLC和UV方法研究了腺苷钻胺在不同物理状态和不同pH溶剂中受不同光强度照射后的光解情况,结果表明在相同光强下本品固体状态较液体状态稳定得多,在酸性缓冲液中(pH2.0)降解较中性缓冲液(pH7.0)、水(pH5.5)慢、在相同物理状态下光强度越大则光解速度越快,提示本品原料应避光保存,而溶液由于降解较快,应避光操作并尽快测定。The paper studied the photolysis of cobamamide under different light intensites. The result showed that the solid state of Cobamamide was more stable than the liquid state, and the photolysis of cobamamide in acid buffer(pH2. 0) was slower than that in neutral buffer and water (pH 5. 5) under the same light intensity. In the same physical state, the more light intensity, the more photolysis speed. The test indicated that the solid state must be protected from light, and the solution must be measured as quickly as possible under the conditions protected from light.

关 键 词：腺苷钴胺 光解 维生素B12 药物分析 

分 类 号：R977.22[医药卫生—药品] R927.2[医药卫生—药学]