杭州市人群脊髓灰质炎抗体水平监测结果  

Surveillance on Poliomyelitis Antibody Level of Population in Hangzhou

作　　者：黄利明[1] 许二萍[1] 祝水芬[1] 杨洛贤[1] 朱冰[1] 张小平[1] 刘艳[1] 

机构地区：[1]杭州市疾病预防控制中心,浙江杭州310006

出　　处：《浙江预防医学》2008年第2期13-14,18,共3页Zhejiang Journal of Preventive Medicine

基　　金：杭州市卫生局(2005B098)

摘　　要：目的了解杭州市健康人群脊髓灰质炎（脊灰）抗体水平,为及时制定免疫策略提供科学依据。方法2001-2005年分别对2-4岁、6-8岁、13-15岁、25-39岁4个年龄组共计947人进行脊灰中和抗体水平监测。结果共抽取947人,脊灰Ⅰ、Ⅱ、Ⅲ型中和抗体阳性率分别为99.58%、98.94%和99.47%,GMT分别为1：648.08、1：394.92,和1：418.23。Ⅰ、Ⅱ、Ⅲ型脊灰抗体GMT比较,差异有统计学意义。不同城区与郊县间Ⅰ、Ⅱ、Ⅲ型抗体阳性率无统计学差异。结论无脊髓灰质炎状态下杭州市计划免疫冷链系统运转状况良好,脊灰疫苗免疫效果显著,健康人群对脊灰已形成牢固的免疫屏障。Objective To understand the poliomyelitis antibody level among healthy people in Hangzhou City and provide scientific evidence for the immunization strategy in tithe. Methods From 2001 to 2005, a surveillance of poliomyelitis neutralizing antibody level was conducted among 947 people, who were divided into 4 groups of 2 - 4, 6 - 8 , 13 - 15 and 25- 39 years old, respectively. Results Neutralizing antibody positive rate for poliomyelitis Ⅰ, Ⅱ and Ⅲ were 99.58 %, 98,94% and 99.47% respectively. The GMTs were 1： 648.08, 1： 394.94, 1： 418.23, respectively, which were statistically significant among the three types of polionryelitis. However, the differences of Neutralizing antibody positive rate for poliomyelitis Ⅰ, Ⅱ and Ⅲ were not statistically significant between urban center and suburb. Conclusion In the polio-free status, the EPI cold chain system operated well in Hangzhou City and the effect of poliomyelitis vaccine was remarkable. The immune barrier to poliomyelitis among healthy population had been formed firmly.

关 键 词：脊髓灰质炎 中和抗体 监测 

分 类 号：R512.4[医药卫生—内科学]