D-半乳糖致小鼠衰老模型海马突触蛋白的改变  

Changes of Synaptic Protein of Hippocamp in Mouse Aging Model Caused by D-galactose

作　　者：王中林[1,2,3,4] 顾一煌[1,2,3,4] 焦瑞清 徐恒泽[1,2,3,4] 吴馥梅 

机构地区：[1]南京中医药大学第二临床医学院 [2]南京大学生化系生物医学技术国家重点实验室 [3]南京中医药大学科研处 [4]南京大学生物科学与技术系神经生物学研究室

出　　处：《南京中医药大学学报》1997年第4期216-217,共2页Journal of Nanjing University of Traditional Chinese Medicine

摘　　要：用Ｄ－半乳糖所致衰老模型组和正常对照组小鼠的海马制备突触体总蛋白，进行ＳＤＳ－聚丙烯酰胺凝胶电泳及薄层扫描分析。结果：和对照组相比Ｄ－半乳糖造模组海马有８种蛋白的相对百分含量变化大于５％，４种升高，４种降低。Electrophoretic analysis and thin-layer scanning were employed to observe changes of the synaptic protein of hippocamp in mouse aging models caused by D-galactose.The result showed that compared with the control group,the D-galactose group had 8 kinds of protein with changes in the relative percentage greater than 5%,4 kind of protein with increased content and 4 with decreased content.This indicates that D-galactose may influence the multiple synaptic protein of mouse hippocamp.

关 键 词：衰老 突触体 蛋白质 海马 D-半乳糖 

分 类 号：R965[医药卫生—药理学]