慢性肺源性心脏病患者血浆纤维蛋白原(FB)及血气分析的相关性研究  

作　　者：曹卓[1] 刘惠芳[1] 金元虹[1] 潘炯伟[1] 

机构地区：[1]浙江省温州医学院附属第六医院丽水市人民医院,323000

出　　处：《临床肺科杂志》2008年第3期297-298,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨慢性肺心病患者血浆纤维蛋白原(FB)水平及与血气分析相关性。方法对126例慢性肺心病患者治疗前后血气分析、血浆纤维蛋白原及30例对照组的血浆纤维蛋白原分别进行测定。结果血浆纤维白原水平在慢性肺心病加重期患者明显升高,与对照组相比有显著性差异;治疗后血浆纤维蛋白原明显下降,与对照组相比均有显著性差异;血浆纤维蛋白原与动脉血氧分压(PaO2)呈负相关。血浆纤维蛋白原与动脉血二氧化碳分压(PaCO2)呈正相关。结论慢性肺心病患者血浆纤维蛋白原增高,易导致肺小动脉血栓形成、低氧血症和高碳酸血症。临床应改善缺氧、通气及适当的抗凝治疗对控制病情有益。Objective To study the change of plasma fibrinogen and correlation with blood gas analysis in chronic Lung Secret Concern Patients. Methods The plasma fibrinogen level was measured in 30 patients with chronic Lung Secret Concern and 30 controls. Blood gas analysis was measured in 30 patients with chronic Lung Secret Concern disease. Results The plasma fibrinogen level was apparently higher in exacerbated patients than in controls. After treatment, the plasma fibrinogen level was significantly low,but there was no significantly difference aeompared with controls. The plasma fibrinogen level was negatively correlated with PaO2. The plasma fibrinogen level was positively correlated with PaCO2. Conclusion The Elevated plasma fibrinogen level maybe associated with hypereoagulability state of chronic Lung Secret Concern disease and contributes to thrombi in small pulmonary arteries and arterioles. Hypoxemia and hypereapnia were correlated with the elevated plasma fibrinogen level. The improvement of hypoxemia, ventilation and the anti-coagulability medicine treatment are benefit for chronic Lung Secret Concern patients.

关 键 词：慢性肺心病 纤维蛋白原 血气分析 血栓 

分 类 号：R541.5[医药卫生—心血管疾病]