One-pot synthesis,antibacterial and antifungal activities of novel 2,5-disubstituted-1,3,4-oxadiazoles  

作　　者：Abdul Rauf Shweta Sharma Saloni Gangal 

机构地区：[1]Department of Chemistry,Aligarh Muslim University,Aligarh 202002,India

出　　处：《Chinese Chemical Letters》2008年第1期5-8,共4页中国化学快报（英文版）

摘　　要：A series of novel 2,5-disubstituted-1,3,4-oxadiazoles have been synthesized from long-chain alkanoic and alkenoic acids. The structures of these compounds have been elucidated by elemental and spectral （IR, ^1H NMR, ^13C NMR, MS） analysis. Furthermore, compounds were screened for in vitro antibacterial activity against the representative panel of two Gram-positive and two Gram- negative bacteria. All the synthesized compounds were also tested for their inhibitory action against five strains of fungus. The various compounds show potent inhibitory action against test organisms. 2007 Abdul Rauf. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.A series of novel 2,5-disubstituted-1,3,4-oxadiazoles have been synthesized from long-chain alkanoic and alkenoic acids. The structures of these compounds have been elucidated by elemental and spectral （IR, ^1H NMR, ^13C NMR, MS） analysis. Furthermore, compounds were screened for in vitro antibacterial activity against the representative panel of two Gram-positive and two Gram- negative bacteria. All the synthesized compounds were also tested for their inhibitory action against five strains of fungus. The various compounds show potent inhibitory action against test organisms. 2007 Abdul Rauf. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：2 5-Disubstituted-l 3 4-oxadiazoles Antibacterial activity Antifungal activity 

分 类 号：O626[理学—有机化学]