松针提取液对高脂膳家兔血脂与脂质过氧化的影响  

Effect of pine-needle extract on blood lipids level and lipid peroxidation in high fat diets rabbits

作　　者：蒋汝刚[1] 罗德生[2] 

机构地区：[1]咸宁学院预防医学教研室,湖北咸宁437100 [2]咸宁学院生物化学教研室,湖北咸宁437100

出　　处：《中国民康医学》2008年第4期263-264,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨松针提取液对高脂膳家兔血脂及脂质过氧化的影响。方法:经8周高脂乳剂饲养后,选高脂血症造模成功的家兔15只,随机分为对照组、松针提取液低剂量组(治疗Ⅰ组)、松针提取液高剂量组(治疗Ⅱ组)。取血测定总胆固醇(TC)、甘油三酯(TG)、丙二醛(MDA)、超氧化物歧化酶(SOD)活性和总抗氧化活力等指标。结果:经松针提取液治疗后,血清TC、TG及MDA含量降低,SOD活性及总抗氧化活力升高,与对照组比较,治疗Ⅱ组的降脂作用和抗氧化能力更显著。结论:松针提取液对高脂膳家兔有降血脂和抗脂质过氧化的作用。Objective： To study the comprehensive effect of pine - needle extract on blood lipids level and lipid peroxidation in high fat diets rabbits. Methods： 15 rabbits with hyperlipidemia successfully induced by feeding hyperlipidic emulsion for 8 weeks were randomly divided into the control group, treating group Ⅰ（treated with a small dose of the liquid pine needle extract）and treating group Ⅱ （treated with a large dose of the extract）. A certain volume of blood was drawn from the rabbits to determine the levels of TG, TC, MDA, and SOD activity, and total anti - oxidizing capacity in the serum.Results：After the treatment with the liquid pine needle extract, the levels of TC ,TG and MDA were lower, and SOD activity and total anti - oxidizing capacity were higher in both treating groups; and compared with the control group, the extract showed stronger effects in treating group Ⅱ.Conclusion： The extract has fairly strong effects of reducing blood lipid and resisting oxidization.

关 键 词：血脂 高脂血症 脂质过氧化 松针提取液 

分 类 号：R285.5[医药卫生—中药学]