聚焦超声治疗外阴上皮内非瘤样病变的有效性研究  

Effectiveness of Focused Ultrasound Therapy for Non-neoplastic Epithelial Disorders of Vulva

作　　者：杨晓[1] 李成志[1] 吴艺佳[2] 蒋玲[3] 汪炼 田耘博[1] 王智彪[1] 

机构地区：[1]重庆医科大学医学超声工程研究所,重庆400016 [2]重庆医科大学附属第二临床医院,重庆400010 [3]重庆市第三人民医院,重庆400014 [4]重庆市江北区第一人民医院,重庆400020

出　　处：《中国循证医学杂志》2008年第2期90-92,共3页Chinese Journal of Evidence-based Medicine

基　　金：重庆市科委自然科学基金重点项目(渝科发计字No.Ezoo4-147);教育部“长江学者与创新团队发展计划”生物医学超声项目(教技函No.E2oo5333)

摘　　要：目的评价超声治疗外阴上皮内非瘤样病变的临床疗效。方法根据随机化数字表按2∶1的比例,将经病理确诊的90例外阴上皮内非瘤样病变患者随机分为超声治疗组(60例)和光谱治疗对照组(30例),于治疗后6个月评价两组的近期疗效和复发率。结果超声治疗组临床治愈29例,显效25例,好转6例,复发5例;光谱治疗组临床治愈1例,显效6例,好转19例,无效4例,复发21例。超声治疗组疗效优秀于对照组(Z=-6.191,P=0.000),且复发率更低(χ2=-37.02,P=0.000),差异均有统计学意义。结论超声是目前治疗外阴上皮内非瘤样病变的一种有效方法。Objective To investigate the clinical effectiveness of focused ultrasound therapy for non-neoplastic epithelial disorders of vulva. Methods Totally 90 patients with pathologically confirmed non-neoplastic epithelial disorders of vulva were enrolled in the study and randomized to receive ultrasound therapy 60 patients or spectrum therapy （30 patients）. The short-term effectiveness and recurrence rate were assessed in both groups at 6 months after treatment. Results In the ultrasound group, 29 cases were cured, 25 were significantly improved, 6 were improved and 5 experienced recurrence. Whereas, in the control group, 1 case was cured, 25 were significantly improved, 4 remained unchanged and 21 experienced recurrence. The short-term effectiveness of ultrasound therapy was superior to that of spectrum therapy （Z=-6.191, P=0.000）. And ultrasound therapy was associated with a significantly lower rate of recurrence （X^2=-37.02, P=0.000）. Conclusions The focused ultrasound therapy appears to be an effective approach in the treatment of non-neoplastic epithelial disorders of vulva.

关 键 词：聚焦超声治疗 外阴上皮 非瘤样病变 有效性 病例 

分 类 号：R454.2[医药卫生—治疗学] R711.7[医药卫生—临床医学]