拉氧头孢钠的极谱行为及其痕量测定方法  

POLAROGRAPHIC BEHAVIOR OF LATAMOXEF SODIUM AND ITS TRACE DETERMINATION

作　　者：顾海鹰[1,2,3] 孙登明[1,2,3] 俞爱民[1,2,3] 陈洪渊 

机构地区：[1]南京大学化学系 [2]南通医学院 [3]淮北煤炭师范学院

出　　处：《药学学报》1997年第5期373-376,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金;教委博士点基金

摘　　要：在ＨＣｌ—ＫＣｌ（ｐＨ１～２）介质中，用循环伏安和示差脉冲极谱（ＤＰＰ）等电化学方法研究了拉氧头孢钠（噻吗灵）的电极反应机理，并建立了用ＤＰＰ测定的新方法。其峰电位为－０６２Ｖ（ｖｓＡｇ／ＡｇＣｌ），峰电流与拉氧头孢钠浓度在１×１０－８～５×１０－６ｍｏｌ·Ｌ－１（富集时间ｔａｃ＝９０ｓ），５×１０－６～５×１０－５ｍｏｌ·Ｌ－１（ｔａｃ＝７０ｓ），５×１０－５～８×１０－４ｍｏｌ·Ｌ－１（ｔａｃ＝３０ｓ）范围内成线性关系。检测限为４×１０－９ｍｏｌ·Ｌ－１（ｔａｃ＝９０ｓ）。本法可用于注射剂中该物质的测定，同时也探讨了直接测定尿中拉氧头孢钠的可能性。In the medium of HCl—KCl (pH 1～2) by means of cyclic voltammetry and differential pulse polarography (DPP),the mechanism of the electrode reaction for latamoxef sodium (Shiomarin) at static mercury drop electrode (SMDE) and hanging mercury drop electrode (HMDE) has been proposed. A sensitive method for the determination of nanomolar concentration of latamoxef sodium by DPP was developed. The peak potential was -0 62 V (vs Ag/AgCl). The linear range was from 1×10 -8 to 8×10 -4 mol·L -1 , the detection limit was ca. 4×10 -9 mol·L -1 ( t ac =90 s). The method was applied to the determination of latamoxef sodium in injection with satisfactory results. The possibility for the direct determination of latamoxef sodium in mimic urine sample was also studied.

关 键 词：拉氧头孢钠 循环伏安法 示差脉冲极谱法 抗生素 

分 类 号：R978.11[医药卫生—药品]