思瑞康与氯丙嗪对首发精神分裂症患者认知功能的影响  

A Comparison of Cognitive Founction in First Episode Schizophrenia Treated with Seroquel or Chlorpromazine

作　　者：宁征远[1] 刘淑萍 靳士军 

机构地区：[1]中国.河北省精神卫生中心,保定市071000

出　　处：《中国健康心理学杂志》2008年第2期138-140,共3页China Journal of Health Psychology

摘　　要：目的比较思瑞康与氯丙嗪对首发精神分裂症患者认知功能的影响。方法将符合CCMD-3诊断标准的首发精神分裂症患者60例随机分为两组,分别给予思瑞康与氯丙嗪治疗8周。分别于入组前及治疗8周末,测查威斯康星卡片分类试验(WCST)、数字划销试验(CT)、韦氏成人智力测验(WAIS-RC)。结果治疗后思瑞康组的WAIS、CT、WCST等成绩明显好于氯丙嗪组。结论思瑞康对首发精神分裂症患者的认知改善优于氯丙嗪。Objective To compare the effecacy of seroquel with chlorpromazine on cognitive function in first episode schizophrenia patients. Methods Sixty patients with first episode schizophrenia were randomly divided into two groups, treated with seroquel or chlorpromazine for 8 weeks, patients were tested with the Wisconsin Card Sort Test （WCST）, the Caneellation Test （CT）, the Weehsler adult intelligence scale（WAIS）. Results The group of seroquel is significantly better than chlorpromazine in WAIS, CT, WCST. Conelusion Seroquel is better than chlorpromazine in improving cognitive impairments for patients with first episode schizophrenia.

关 键 词：首发精神分裂症 认知功能 思瑞康 氯丙嗪 

分 类 号：R971.4[医药卫生—药品] R749.16[医药卫生—药学]