滇产三七固态生物转化产物的初步药理研究  

Primary pharmacological studies on the saponins from the solid fermented roots of Radix Notoginseng produced in Yunnan province

作　　者：马伟光[1] 赵云丽 汪霞 廖伟 尚建华 黄之镨[1] 彭友良[1] 张庆芝[1] 张超[1] 

机构地区：[1]云南中医学院,昆明650200 [2]云南药物研究所,昆明650111

出　　处：《中华中医药杂志》2008年第3期260-263,共4页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:对三七生药生物转化后所提总皂苷进行药理研究,初步判断转化效果。方法:采用断头脑缺血、体内血栓形成、氯仿致心律失常及离体心脏灌流实验。结果:腹腔注射1号-5号样品100、200mg/kg,对断头脑缺血小鼠均有明显保护作用;1号200mg.kg-1.d-1×5d,能明显抑制胶原-肾上腺素诱导小鼠体内血栓形成;除1号100mg/kg外,各组均能明显对抗氯仿诱发小鼠心律失常,3、4号高剂量与5号高剂量组相比室颤发生率有所降低;与生理盐水对照组相比,1-4号保留了扩张冠脉,但对心肌收缩力和心脏前负荷的影响各有差异。结论:转化后样品与对照品在药理作用上发生了一定变化,提示转化后的三七总皂苷化学结构可能有所变化,与初步的化学分析结果相吻合。Objective： To compare the pharmacodynamic action of Radix Notoginseng after fermented by different strains bioconversion. Methods： The models of cerebral ischemia and hypoxia were established , thrombosis in vivo were induced by collagen-Adr, ventricular fibrillation of mice by chloroform, and perfusion experiment of the ex vivo heart of cavia cobaya was used. Results： 100, 200mg/kg doses of all samples had protective effects on ischemia and hypoxia mice, 1 # sample can inhibit thrombosis induced by collagen-adrenaline obviously after intraperitoneal injection in dosage of 200mg· kg^- 1 ·d^- 1 for 5days. All groups significantly reduced the incidents of ventricullar fibrillation induced by chloroform in mice except 100mg/kg dose of 1 # , furthermore, compared with control high dose group （5 # ）, the incidents of high dose groups of 3,4 # deceased significantly. All samples had the effect of dilating coronary artery,but there effects on myocardial contractile force and cardiac preload were different. Conclusion：The primary cardiovascular related pharmacological researches demonstrated the vary action changes of 1 - 4 # samples compared with the sample 5 # . This result has revealed that the chemical structure of Radix Notoginseng transformed and that is coincide with initial analysis of phytochemical analysis.

关 键 词：三七 生物转化 药理研究 

分 类 号：R285[医药卫生—中药学]