2型糖尿病病程与冠心病病变程度的相关性分析  

Relativity between Duration of Type 2 Diabetes Mellitus and Pathological Changes of Coronary Heart Disease

作　　者：张弢[1] 刘宏斌[1] 巩维如[1] 刘国树[1] 巩琰[1] 

机构地区：[1]解放军总医院心内科,北京市100853

出　　处：《中国康复理论与实践》2008年第2期173-174,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨不同年限2型糖尿病合并冠心病患者的冠状动脉造影特点。方法从冠状动脉造影病例中选取符合冠心病诊断标准的病例206例,其中非糖尿病患者62例、2型糖尿病患者124例(病程≤5年41例、>5年～≤10年38例、>10年～≤20年45例)。分析比较各组之间的临床资料和冠状动脉病变特点。结果糖尿病≤5年组和>5年～≤10年组冠状动脉的病变数量以及病变程度、形态与非糖尿病组比较,差异均无统计学意义;而糖尿病>10年～≤20年组患者冠状动脉发生多支病变以及弥漫病变、闭塞病变明显高于其他组(P<0.01)。结论随2型糖尿病病程的延长,冠状动脉病变逐渐广泛和严重。Objective To investigate the correlation of diabetes duration and coronary arterial pathological changes by coronary angiography in patients with coronary heart disease and type 2 diabetes mellitus. Methods 206 patients with coronary heart disease admitted into the hospital were divided into 4 groups： no diabetes （n=62）, the duration of diabetes ≤5 years （n=41）, 〉5～≤10 years （n=38） and 〉10～≤20 years （n=45）. The interventional therapy history and type 1 diabetes mellitus were excluded. The pathologic changes of coronary artery evaluated by coronary angiography and the results among different groups were analyzed with the diabetes duration. Results There was no significant differences in the pathological changes of coronary artery between the group of no diabetes and the groups of ≤5 years duration and 〉5～≤10 years duration. However, the group of 〉10～≤20 years duration showed more serious pathologic changes of coronary artery than other groups including the multi-branch lesion, diffuse lesion and obstruct lesion （P 〈0.01）. Conclusion Following the process of the diabetes, the coronary lesions in patients with type 2 diabetes mellitus tend to be more widespread and severe.

关 键 词：冠心病 2型糖尿病 病程 冠状血管造影术 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]