比索洛尔和卡维地洛对高血压患者的疗效比较  

Comparison of bisoprolol and carvidilol in antihypertensive effects and reversing left ventricular hypertrophy in patients with essential hypertension

作　　者：彭晓玲[1] 林泽鹏[1] 张少敏[1] 朱蕾[1] 张志伟[1] 孙晓红[1] 

机构地区：[1]深圳市孙逸仙心血管医院心内科,广东省深圳518020

出　　处：《中国基层医药》2007年第12期1989-1991,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的比较卡维地洛与比索洛尔治疗轻中度高血压病的临床疗效。方法40例轻中度原发性高血压患者随机分为卡维地洛组(20例)和比索洛尔组(20例),疗程24周。在治疗过程中测量坐位血压和心率,并记录不良反应,并做血常规、血生化和心脏超声检查。结果两组治疗后患者收缩压、舒张压及心率均有显著下降(P<0.05～P<0.01),而两组间差异不明显。卡维地洛组左室肥厚各项指标均较治疗前明显改善(P<0.05),而比索洛尔组治疗前后无明显差异;对血脂、血糖、肝肾功能无显著影响。卡维地洛的不良反应较比索洛尔少且轻微。结论卡维地洛治疗原发性高血压疗效确切,可减轻左心室肥厚,改善左心室的舒张功能,可能较比索洛尔更加有益于减少心血管事件的发生。Objective To investigate the effects of antihypertension and reversing left ventricular hypertrophy by earvedilol or bisoprolol in patients with mild to moderate essential hypertension. Methods 40 cases of mild to moderate essential hypertension patients were selected for this random single-blind, paralleling controlled clinical study. Results Patients were randomized to take 12.5-25mg carvedilol tablet once daily or bisoprolol 2.5-5mg once daily if DBP was still in the range of 12.0-14.6kPa（90-110mmHg） after 2 weeks＇ placebo baseline. Carvedilol group included 20 cases, bisoprolol group included 20 cases, and the course was 24 weeks. Blood pressure and heart rate were measured and symptoms and signs were recorded. At the end of placebo and in 24 weeks heart ultrasound,blood routine,serum glucose, blood lipid, hepatic function and renal function were examined. SBP, DBP and heart rate of patients in two groups decreased obviously. There were significant differences between the two groups. Ventrlcular hypertrophy of carvedilol group improved than that in pretherapy. There were significant differ-ences between the two groups. Conclusion Carvedilol was well-tolerated with less side effects such as mild headache, tiredness, dizziness,slightly elevating of serum glucose. Carvedilol could well treat the mild moderate essential hypertension effectively and safely by 12.5- 25mg once daily.

关 键 词：卡维地洛 比索洛尔 原发性高血压 左心室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病] R541.6[医药卫生—内科学]