浙江省湖州市自然人群甲型及戊型肝炎IgG抗体平行检测结果分析  

Parallel detection of HAV- IgG and HEV- IgG in natural population in Huzhou City

作　　者：沈建勇[1] 韩建康[1] 金玫华[1] 姚文庭[1] 邹勇[1] 

机构地区：[1]浙江省湖州市疾病预防控制中心,浙江湖州313000

出　　处：《疾病监测》2007年第12期809-811,共3页Disease Surveillance

基　　金：湖州市社会发展科研基金支持项目(No:2006YS15)

摘　　要：目的分析浙江省湖州市甲、戊型肝炎(甲肝、戊肝)血清流行病学特征,探讨防制对策。方法在湖州市范围内按农村平原水乡、农村山区和城镇 3群,随机抽取1666名健康人作为研究对象,进行流行病学个案调查和血清甲型肝炎抗体(抗-HAV-IgG)及戊型肝炎(抗-HEV-IgG)检测。结果湖州市自然人群甲肝、戊肝标化感染率分别为55.74%和38.88%,感染率均与年龄呈正相关;甲肝感染率城镇高于水乡,戊肝则城镇和平原水乡高于山区;甲戊型肝炎重叠感染率32.23%,两型肝炎感染存在统计学关联;戊肝及甲戊型肝炎重叠感染均存在家庭聚集性现象。结论应结合甲肝、戊肝血清流行病学特征开展相关防制工作,同时在检测HAV时应注意HEV的检测。Objective The present study was designed to find out the sero-epidemiological characteristics of HAV and HEV in natural population in Huzhou city for the development of preventive and control strategies. Methods A random sampling method was used to select subjects from the plain rural region of rivers and lakes, the mountain rural area and the towns in the city of Huzhou, with a total of 1666 healthy individuals included and clustered into 3 groups, in whom case study and serological detection of anti-HAV-IgG and anti-HEV-IgG were conducted on an epidemiological basis. Results The standardized infectious rates of HAV and HEV in the natural population in the city of Huzhou were 55.74% and 38.88% ,respectively, which were positively correlated with age. The infectious rate of HAV in towns was higher than that in the plain rural region of rivers and lakes, while the rate of HEV in towns and the region was higher than that in mountain rural area. Both the infectious rate of HAV and HEV had positive correlations with ages. The coinfection rate of HAV and HEV was 32.23% with a statistical association between them. HEV and coinfection of HAV and HEV presented a trend of familial aggregation. Conclusion It is advisable to detect HEV at the same time of HAV diagnostic test. Prevention and control of the epidemics should be conducted based on their epidemiological characteristics.

关 键 词：甲型肝炎 戊型肝炎 血清流行病学 重叠感染 家庭聚集性 

分 类 号：R446.6[医药卫生—诊断学]