非甾体消炎药对上消化道损伤的胃镜观察  

Investigation of Gastroduodenal Lesions induced by Nonsteriodal Anti-inflammatory Drugs

作　　者：刘玉兰 

机构地区：[1]广东省广州市番禺区沙湾人民医院内科,广东广州511483

出　　处：《医学信息》2008年第3期377-378,共2页Journal of Medical Information

摘　　要：目的探讨非甾体消炎药(NSAID)相关胃肠粘膜损伤的特点。方法应用胃镜连续观察166例上消化道出血的患者,根据是否服用NSAID分为NSAID组(1组)和非NSAID组(2组)。结果两组胃粘膜糜烂患者分别为57.9%、37.2%;胃溃疡30.8%和27.1%;十二指肠溃疡11.3%和35.7%,NSAID组胃溃疡患者(33例)中有21例为胃窦溃疡,占63.6%,胃体溃疡12例,占36.4%;而对照组(16例)中胃窦溃疡9例(56.3%),胃体溃疡7例(43.7%),统计学显示两组在构成比方面有显著性差异(P﹤0.01)。结论NSAID相关的胃肠粘膜损伤镜下有其特征性。Objective To investigate the association between nonsteroidal anti-inflammatory drugs and gastreduedenal lesions by gastroscopy. Method Observe 166 patients consecutively by gastroscopy who were diagnosed upper alimentary tract hemorrhage. The patients were divided in NSAID-related and non-NSAID-related groups（group 1 and group 2） according to whether taking NSAID or not. Result According to the examination of gastroscopy, gastroduodenal lesions were divided into three types： acute erosive gastritis and gastic ulcer and duodenal ulcer. These kinds of patients accounted for 57.9% and 30.8% and 11.3% respectively in group 1. For group 2, it was 37.2% and 27.1% and 35.7%. Conclusion There are more typical manifestations in patients＇ gastroduodenal lesions who used NSAID.

关 键 词：非甾体消炎药 胃肠粘膜损伤 胃镜 

分 类 号：R971.1[医药卫生—药品] R972.1[医药卫生—药学]