人参健心胶囊对冠心病患者胰岛素抵抗及纤维蛋白溶解活性的影响  

Effect of Renshen Jianxin Capsule on Insulin Resistance and Coagulation in Coronary Heart Disease

作　　者：李爱民[1] 

机构地区：[1]中国人民解放军第456医院,山东济南250031

出　　处：《中国中医药信息杂志》2008年第2期12-13,共2页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的观察人参健心胶囊对冠心病患者胰岛素抵抗、纤维蛋白溶解活性的影响。方法将符合冠心病气虚血瘀型诊断标准的60例患者随机分为试验组和对照组,每组各30例。在硝酸酯类等治疗的基础上,试验组口服人参健心胶囊,对照组口服二甲双胍,疗程6周。观察2组患者治疗前后空腹血糖、胰岛素、胰岛素敏感指数(ISI)、纤溶酶原激活剂抑制物-1(PAI-1)的变化。结果人参健心胶囊试验组治疗后胰岛素明显降低、ISI明显升高,PAI-1明显降低;对照组治疗后PAI-1与治疗前比较无显著差异。结论人参健心胶囊可以改善冠心病患者的胰岛素抵抗,作用与二甲双胍相似;改善纤维蛋白溶解活性受损作用明显,优于二甲双胍。Objective To explore the effect of Renshen Jianxin Capsule on insulin resistance and coagulation in coronary heart disease. Methods Angina patients with Qi dificiency and blood stasis were randomly divided into Renshen Jianxin Capsule group （30 patients, treated by Renshen Jianxin Capsule and common western medicine） and metformin group （30 patients, treated by metformin and common western medicine）. The changes of blood glucose, insulin sensitivity index （ISI）, plasminogen activator inhibitor-1 （PAI-1） were observed after six weeks. Results Blood glucose and PAI-1 were decreased, ISI was improved significantly after treatment of Renshen Jianxin Capsule. There was no significant difference of PAI-1 in metformin group. Conclution Renshen Jianxin Capsule has similar effect with metformin in improving insulin resistance and better effect in improving coagulation.

关 键 词：人参健心胶囊 冠心病 胰岛素抵抗 纤维蛋白溶解活性 

分 类 号：R259.487[医药卫生—中西医结合]