解毒通络调肝散对糖尿病胰岛素抵抗模型大鼠的影响  

Study on Insulin Resistance of Preventing and Treating Experimental Diabetic Rats by Powder of Detoxicating and Activating the Collaterals and Regulating Livers

作　　者：朱亚春[1] 朴春丽[2] 于淼[3] 李瑞恩[1] 南征[2] 

机构地区：[1]中国中医科学院,北京100700 [2]长春中医药大学附属医院,吉林长春130021 [3]吉林省人民医院,吉林长春130021

出　　处：《中国中医药信息杂志》2008年第2期20-22,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：吉林省科技厅资助(20050568)

摘　　要：目的研究解毒通络调肝散对高脂饲料与链脲佐菌素诱导的大鼠糖尿病模型的药效作用,为临床用药提供科学依据。方法以高脂饲料喂饲Wistar大鼠1个月后,禁食12h,腹腔注射1.2%链脲佐菌素30mg/kg,空白组注射等体积柠檬酸缓冲液。将造模成功的大鼠随机分为模型组、二甲双胍组、吡咯列酮组和解毒通络调肝组。治疗组分别按0.5、5、5g/(kg·d)的剂量灌胃给予不同药物,空白组和模型组给予等体积生理盐水。给药2个月后进行各指标检测。结果解毒通络调肝散治疗组第12周血糖、糖化血红蛋白、血清胰岛素、血清总胆固醇、三酰甘油水平均明显低于模型组(P<0.05或P<0.01),胰岛素敏感指数高于模型组(P<0.01)。各指标与治疗组相比亦有不同程度差别(P<0.05或P<0.01)。结论解毒通络调肝散能显著降低该动物模型的空腹血糖、糖化血红蛋白,调节血脂,改善胰岛素敏感性。Objective To research the effects of powder of detoxicating and activating the coUaterals and regulating livers on diabetic rats models caused by high fat feed and streptozotocin, to provide scientific basis for clinical dosage. Methods Wistar rats were feeded by high fat feed for one month and forbidden to eat for twelve hours, then injected through abdomen with 30 mg/kg of 1.2% streptozotocin. Blank group was injected with the same amount of lemon buffer solution. One week later, sugar tolenrance test was conducted. Rats affected by diabetics were divided into model group, dimethyldiguanide group, Pyrrole group and group of detoxicating and activating the coUaterals and regulating livers. Treatment group was perfused into stomach with different medicine by the dosage of 0.5, 5, 0.5 g/（kg·d） respectively. Blank group and model group were perfused with the same amount of physiological saline. Two months after the dosage, indexes such as saccharogenic hemoglobian and blood lipid were detected, and the sensitive indexes of insulin was calculated. Results In the twelfth week, every index in treatment group by powder of detoxicafing and activating the collaterals and regulating livers was much lower than model group （P〈0.05 or P〈0.01）. Conclusion Powder of detoxicating and activating the coUaterals and regulating livers can remarkably reduce blood sugar and saccharogenic hemoglobian, regulate blood fat, and improve insulin sensitivity.

关 键 词：解毒通络调肝散 2型糖尿病 胰岛素抵抗 大鼠 

分 类 号：R285.5[医药卫生—中药学]