低能量氦-氖激光血管内照射联合中药对糖尿病脑梗死家兔的影响  

Effect of Intravenous Low Intensity Laser Radiation Combined with TCM on Model Rabbit of Diabetic Stroke

作　　者：王波[1] 魏海峰[2] 林兰[3] 刘喜明[3] 楚小燕[3] 王兆礼[3] 

机构地区：[1]中国人民解放军总医院第二附属医院,北京100091 [2]首都医科大学宣武医院,北京100053 [3]中国中医科学院广安门医院,北京100053

出　　处：《中国中医药信息杂志》2008年第2期30-32,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金资助(696448001)

摘　　要：目的观察低能量氦-氖激光血管内照射(ILLLI)配合中药治疗对实验性糖尿病脑梗死家兔血浆血栓素(TXB2)、6-酮前列环素(6-Keto-PGF1α)和血管紧张素Ⅱ(AngⅡ)水平的影响。方法经四氧嘧啶造成糖尿病及光化学方法造成的高脂家兔糖尿病脑梗死模型35只,分为模型组、单纯激光照射组、糖脑络通方治疗组、激光+中药组并进行不同治疗,测其血浆TXB2、6-Keto-PGF1α及AngⅡ水平,进行组间比较及与正常组比较。结果与模型组比较,单纯激光和中药组均能降低TXB2及AngⅡ、升高6-Keto-PGF1α水平,而激光联合中药组作用更明显。结论低能量氦-氖激光血管内照射联合中药糖脑络通方可显著降低TXB2和AngⅡ、升高6-Keto-PGF1α水平,从而达到治疗糖尿病脑梗死的目的。Objective To observe the effect of intravenous low intensity laser radiation （ILLLI） combined with traditional Chinese medicine on TXB2, 6-Keto-PGFIo and Ang II of the rabbits of experimental diabetic stroke. Method 35 successfully modeled rabbits, after alloxian injection for diabetes and photochemical radiation for stroke, were randomized into four treatment group-control group （B）, ILIB group （C）, a group with compound treatment of ILIB and TCH （D）, TCM treatment group （E）, and 7 unmodeled rabbits were made as the normal group （A）. TXB2, 6-Keto-PGFIo and Ang Ⅱ level were observed and compared. Result Compared with group B, group C and E can significantly rectify the disorderly TXB2. 6-Keto-PGF1oand Ang Ⅱ, Group D was better than C and E. Conclusion ILLLI combined with TCM can effectively rectify the TXB2, 6-Keto-PGFIo and Ang Ⅱ level, reduce nervous injury, cure diabetes cerebral infarction.

关 键 词：糖尿病 脑梗死 低能量氦-氖激光血管内照射 糖脑络通汤 血栓素 6-酮前列环素 血管紧张素Ⅱ 

分 类 号：R285.5[医药卫生—中药学]