石菖蒲、肉豆蔻、橘皮挥发油对雪上一枝蒿总碱经皮渗透的影响  

Effects of Volatile Oil of Rhizoma Zingiberis and Other 2 Kinds of Volatile Oil on Percutaneous Penetration of Total Alkali of Shortstalk Monkshood Root

作　　者：白一岑[1] 李艳杰[1] 马云淑[1] 

机构地区：[1]云南中医学院中药学院,云南昆明650200

出　　处：《中国中医药信息杂志》2008年第2期38-40,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金资助(30560187)

摘　　要：目的考察石菖蒲、肉豆蔻、橘皮所含挥发油对雪上一枝蒿总碱经皮渗透的影响。方法采用改良Franz扩散池法,以小鼠皮肤为透皮屏障,用HPLC法测定模型药物雪上一枝蒿总碱中甲素的累积渗透量,并以氮酮为对照,考察不同浓度石菖蒲、肉豆蔻、橘皮所含3种挥发油对雪上一枝蒿甲素的促渗效果。结果7%石菖蒲、7%肉豆蔻挥发油与3%氮酮对雪上一枝蒿总碱的促渗效果最好,渗透系数分别为5.88、6.91、5.30、5.75;与无促渗剂组相比,促渗倍数分别为1.09、1.28、0.98、1.06倍。结论7%石菖蒲、7%肉豆蔻挥发油均能促进雪上一枝蒿甲素的经皮渗透,5%橘皮挥发油无明显促渗作用。Objective To investigate the effects of volatile oils of Rhizoma Acori Tatarinowii （RAT）, Semen Myristicae （SM） and Pericarpium Citri Reticulatae （PCR） on percutaneous penetration of total alkali of Shortstalk Monkshood Root through mouse skin in vitro. Methods By using an improved Franz diffusion cells, the effects of these 3 kinds of volatile oil on the percutaneous penetration of total alkali of Shortstalk Monkshood Root were observed and compared with Azone, and the cumulative amount of Bullatine A was determined by HPLC. Results 7% （v/v） volatile oil RTA and SM, 5% （v/v） volatile oil of PCR and 3% （v/v） Azone were best concentration, the penetration coefficient were 5.88, 6.91, 5.30, 5.75, respectively. Compared with the group without penetration enhencers, the enhancement ratios were 1.09,1.28, 0.98, 1.06, respectively. Conclusion The volatile oil of RAT and SM enhance penetration of total alkali of Shortstalk Monkshood Root. The volatile oil of PCR cannot enhance penetration.

关 键 词：促渗剂 雪上一枝蒿 石菖蒲挥发油 肉豆蔻挥发油 橘皮挥发油 

分 类 号：R285[医药卫生—中药学]