线粒体凋亡途径与Bcl-2家族蛋白研究进展  

Research Development on Apoptosis Pathway by Cytomicrosome and Bcl-2 Family Proteins

作　　者：李捷萌[1] 陈彦青[1] 刘荣国[1] 

机构地区：[1]福建医科大学省立临床学院麻醉科,福州350001

出　　处：《医学综述》2008年第4期489-490,共2页Medical Recapitulate

基　　金：福建省自然科学基金计划资助项目(2006J0083)

摘　　要：线粒体是真核生物能量和代谢的中心,也是在细胞凋亡、信号转导中起关键调节作用的细胞器。Bcl-2家族蛋白是重要的细胞凋亡调节因子,包括抑制和促进细胞凋亡两类功能相反的蛋白质。Bcl-2家族蛋白成员间的相互作用对线粒体介导的细胞凋亡起调控作用。现就Bcl-2家族蛋白的发现、结构、功能以及其对线粒体介导细胞调亡的作用机制做一下综述。Cytomicrosome is the center of energy and metabolism of eukaryon. It is also a cellular organ with the critical adjusting fimction in processes of apoptosis signal. Bcl-2 family proteins are regulatory factors of apoptosis, with the two opposite fimction, i. e inhibition and facilitation. The interaction of Bcl-2 family proteins has regulatory effect to the apoptosis mediated by cytomicrosome. This article gave an introduction to the discovery, construction, function of Bcl-2 family proteins and its roles in apoptosis induced by cytomicrosome.

关 键 词：细胞凋亡 线粒体 细胞色素C BCL-2 

分 类 号：R318.04[医药卫生—生物医学工程]