脂联素对β细胞分泌功能影响的研究进展  

Study Progress of the Effect of Adiponectin on Secretary Function of Beta Cell

作　　者：柏林[1] 武晓泓[1] 刘超[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,南京210029

出　　处：《医学综述》2008年第4期505-507,共3页Medical Recapitulate

摘　　要：脂联素作为一种重要的脂肪因子,不仅与胰岛素抵抗有关,也能影响胰岛β细胞分泌功能,但其作用以及作用机制尚存在争论。脂联素对正常胰岛的胰岛素分泌影响无显著性;在胰岛素抵抗者的胰岛,低糖环境下抑制胰岛素产生,高糖环境下则促进胰岛素分泌。脂联素可以提高胰腺β细胞内腺苷酸活化蛋白激酶(AMPK)的活性,但其活性的增加并未伴随ATP比例的增加以及钙离子通道开放的增加;相反,AMPK的激活却抑制胰岛素的分泌。因此,脂联素对胰岛β细胞分泌功能的作用及其与AMPK相关的内在机制值得进一步研究。Adiponectins is an important adipocyte factors, which is not only related to insulin resistance, but also can affect the secretary function of Beta cell. However, its acition and the mechanism is still in controversy. Adiponectins had no obvious effect on the insulin secretion of normal islets, it can inhibit insulin production of islet with insulin insuin resistance under low carbohydrates, while can promote the insulin production under hSgh glucose. Adiponectin can improve the activity of AMPK in islet, but its activity can not increase accompanying with the increasing ratio of ATP and the increasion of opening of calcium channel. On the contratory, the activation of AMPK can inhibit the insulin secretion. So the effect of adiponectins on the secretary function of beta cells and the mechanism about its association with AMPK needs further studying.

关 键 词：脂联素 糖尿病 Β细胞分泌功能 腺苷酸活化蛋白激酶 

分 类 号：R587.1[医药卫生—内分泌]