异位脂肪沉积致非脂肪组织胰岛素抵抗的研究进展  

Study Progress about Insulin Resistance of Non-fatty Issue Resulting from Allotopic Fatty Deposition

作　　者：张华[1] 郑少雄[1] 

机构地区：[1]天津医科大学第二医院内分泌科,天津300211

出　　处：《医学综述》2008年第4期572-574,共3页Medical Recapitulate

摘　　要：脂毒性是指持续的高水平的游离脂肪酸造成的胰岛β细胞和胰岛素靶组织的结构和功能的损害。游离脂肪酸增加,一方面造成胰腺本身的胰岛素抵抗,加剧β细胞的凋亡;另一方面,沉积于肝脏、肌肉等非脂肪组织,造成这些组织的胰岛素抵抗。因此,脂毒性在2型糖尿病的发病中起重要作用。Lipotoxicity refers to the structural and functional damage of β cell of islet and insulin targeted tissue caused by free fatty acid in high level. Increased FFA not only results in insulin resistance in pancreatic gland itself and aggravate the apoptosis of β cell of islet, but also results in insulin resistance in non-fatty tissue by depositing these tissues including liver, muscles and so on. So lipotoxicity plays an important role in the genesis of type 2 diabetes.

关 键 词：脂毒性 胰岛素抵抗 游离脂肪酸 凋亡 

分 类 号：R587.1[医药卫生—内分泌]