血管紧张素原基因G-6A多态性与冠心病的相关性研究  

Study on the association of G-6A polymorphism in the core promoter region of angiotensinogen gene with coronary heart disease

作　　者：杨帆[1] 赵洛沙[1] 郑红[2] 张华[2] 张静华[1] 王培[1] 陈艳[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052 [2]郑州大学基础医学院

出　　处：《山东医药》2008年第1期19-21,共3页Shandong Medical Journal

摘　　要：目的探讨我国河南汉族人群血管紧张素原基因核心启动子区域G-6A多态性与冠心病(CHD)的关系。方法选择504例确诊CHD的患者和512例无心脏病史的健康体检者,运用多聚酶链反应—限制性内切酶片段长度多态性技术(PCR-RFLP)进行G-6A多态性检测。结果CHD组A/A基因型频率是64.9%,高于对照组的54.9%(2χ=10.565,P<0.05);CHD组A等位基因频率是81.4%,高于对照组的73.3%(2χ=19.071,P<0.05)。结论血管紧张素原基因G-6A多态性中A/A纯合子与CHD的发生之间存在相关性,其中A等位基因可能是CHD发病的遗传危险因子。Objective To explore the correlation between the polymorphisms of G-6A in the core promoter region of angiotensinogen gene and coronary heart disease in Henan Han population. Methods A total number of 504 patients with coronary heart disease and 512 healthy controls without coronary heart disease were investigated by case-control study. The polymorphisms of angiotensinogen G-6A were detected by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results The prevalence of the A/A genotypes of G-6A in patient group was 64.9%, higher than that in control group, 54.9% （P 〈 0.05 ）. The prevalence of A allele in patient group was 81.4%, higher than that in control group, 73.3% （ P 〈 0.05 ）. Conclusions There is an association between the presence of the A/A genotypes in angiotensinogen gene and coronary heart disease. ＂A＂ allele can be a marker of genetic susceptibility about coronary heart disease.

关 键 词：血管紧张素原 遗传多态性 冠状动脉疾病 基因型 

分 类 号：R541.4[医药卫生—心血管疾病]