同步辐射衍射增强成像的肝纤维化成像研究  

Investigation of hepatic fibrosis with synchrotron X-ray diffraction enhanced imaging

作　　者：李辉[1] 王泰龄[2] 王雪艳[1] 赵涛[1] 胡春红[1] 鲁玮瑗[1] 王宝恩[3] 赵新颜[3] 朱佩平[4] 黄万霞[4] 袁清习[4] 王寯越[4] 罗述谦[1] 

机构地区：[1]首都医科大学生物医学工程学院 [2]中日友好医院病理科,北京100029 [3]首都医科大学附属北京友谊医院,北京100050 [4]中国科学院高能物理研究所,北京100049

出　　处：《核技术》2008年第2期81-86,共6页Nuclear Techniques

基　　金：国家自然科学基金(60532090,30770593)

摘　　要：本文根据硬X射线衍射增强成像(Diffraction enhanced imaging,DEI)原理,对由人血白蛋白诱导的大鼠肝纤维化模型进行了成像研究。实验在北京同步辐射装置(Beijing Synchrotron Radiation Facility,BSRF)4W1A光束线形貌站完成。结果表明:正常及不同程度肝纤维化模型在DEI图像上差异显著,图像感兴趣区的光强分布及纹理测度也显示出这种差异。DEI成像为肝纤维化的诊断提供了一种潜在的影像学途径。In this paper, imaging investigation of hepatic fibrosis in rats induced by human albumin with hard X-ray diffraction enhanced imaging （DE1） is reported. The experiments were performed at 4W1A beamline of Beijing Syn- chrotron Radiation Facility （BSRF）. The results show that great differences can be observed in DEI images between the normal and diseased rats in different stages of liver fibrosis. The difference can also be revealed by the profile curve and texture measurements on regions of interest. The results show that DEI may be a potential way for diagnosis of hepatic fibrosis.

关 键 词：同步辐射 肝纤维化 X射线衍射增强成像 组织学图像 纹理测度 

分 类 号：O434.1[机械工程—光学工程] R817.1[理学—光学]