双功能偶联剂SPC的一种新合成方法及其碘标记  

A new synthesis route for SPC as a bi-functional linker for radioiodination and its labeling of iodine

作　　者：杨远友[1] 廖家莉[1] 林如山[1] 刘宁[1] 

机构地区：[1]四川大学原子核科学技术研究所,辐射物理及技术教育部重点实验室,四川成都610064

出　　处：《化学研究与应用》2008年第2期162-165,共4页Chemical Research and Application

基　　金：国家自然科学基金资助项目(20170133、20671065);高等学校博士点基金资助项目(20030610016)

摘　　要：N-succinimidyl 5-(tributylstannyl)-3-pyridinecarboxylate(SPC),a potential bi-functional linker for radiohalogenation of proteins,is synthesized via a new route and in normal experimental conditions. The products are characterized by 1H-NMR,MS and HPLC.The resulted SPC is labeled with 131I in a labeling yield of 71.2% and with radiochemical purity of more than 98% after HPLC purification.There are no significant changes in the radiochemical purity for 131I-SIPC after 72h storage at room temperature.N-succinimidyl 5 - （ tributylstannyl ） -3-pyridinecarboxylate （ SPC ）, a potential bi-functional linker for radiohalogenation of proteins,is synthesized via a new route and in normal experimental conditions. The products are characterized by ^1H-NMR, MS and HPLC. The resulted SPC is labeled with ^131I in a labeling yield of 71.2% and with radiochemical purity of more than 98% after HPLC purification. There are no significant changes in the radiochemical purity for ^131I-SIPC after 72h storage at room temperature.

关 键 词：SPC 碘 间接标记 ^131I-SIPC 

分 类 号：R817.9[医药卫生—影像医学与核医学]