碳糊电极阳极吸附伏安法测定雷贝拉唑  

Determination of rabeprazole at a carbon paste electrode by anodic adsorptive voltammetry

作　　者：郭利民[1] 钟世华[2] 李伟[1] 黄叶菊[2] 

机构地区：[1]湖南省益阳市中心医院药剂科,湖南益阳413000 [2]湖南师范大学化学化工学院,湖南长沙410081

出　　处：《药学实践杂志》2008年第1期35-37,共3页Journal of Pharmaceutical Practice

摘　　要：目的：建立测定雷贝拉唑含量的新方法。方法：采用碳糊电极阳极吸附伏安法，在1．8mol／LH2SO4底液中，通过富集用碳糊电极阳极吸附伏安法研究雷贝拉唑的电化学行为。结果：阳极峰电位为0．498V（vs．SCE），峰电流与雷贝拉唑的浓度在4．15×10^-7～3．37×10^-6mol／L范围内呈良好的线性关系，检出限为6．705×10^-11mol／L。结论：本方法简便准确，适用于雷贝拉唑的含量测定。Objective： To establish a new method for the determination of rabeprazole. Methods： Anodic adsorptive voltammetry with a carbon paste electeode（CPE） was used. Rabeprazole was concentrated on the electrode and determined by adsorptive voltammetry in supporting solution of 1.8 mol/L H2 SO4. Results ：The anthodic peak potential of raberazole was at 0.498 V （vs. SCE）. The peak currents were linear with the concentration of rabeprazole over the range of 4. 15×10^-7 -3.73×10^-6mol/L, with the detection limit 6. 705×10^-11 mol/L. Conclusion： This method is suitable for the determination of rabeprazole, and it is covenient and accurate.

关 键 词：雷贝拉唑 碳糊电极 阳极吸附伏安法 

分 类 号：R927.2[医药卫生—药学]